Molecular Probes of Cation-Arene Interactions

这项研究的重点是研究之间的相互作用， 碱金属阳离子通过合成离子通道运输， 和组成离子通道的芳烃官能团。 合成 由二氮杂-18-冠-6亚基组成的通道， 将合成各种长度以定义所需的最小长度 作为离子通道。 不同的芳烃将被连接到 通道开口，并通过间隔物的合成改性， 结合到通道内部，以阐明 芳烃-阳离子相互作用对钠和钾离子转运的影响 频道。 研究生和本科生参与了 研究将被引入到一个重要的，自然的过程建模， 通过模型化合物和合成剪裁这些化合物， 检查过程中涉及的具体相互作用。 有了这个奖项，有机和高分子化学计划 支持乔治戈克尔博士的研究和教育活动， 华盛顿大学分子生物学和药理学系 大学医学院。 戈克尔博士将把他的研究重点放在 合成由许多等价物组成的大分子体系 由分子间隔物连接的环状亚基， 称为离子通道。 这些分子系统， 自然发生的生物系统，将被合成修改， 探索影响钠运动的特定相互作用， 钾离子通过通道。 Gokel博士的教育活动 将涉及培训研究生和本科生在 这些模型系统合成，以及它们作为离子的表征 导线.

This research focuses on examining the role of the interactions between alkali metal cations being transported through synthetic ion channels, and the arene functionalities that make up the ion channel. Synthetic channels composed of diaza-18-crown-6 subunits connected by spacers of various lengths will be synthesized to define the minimum length needed to function as an ion channel. Different arenes will be attached to the channel opening, and by synthetic modification of the spacers, incorporated into the channel interiors to elucidate the effect of arene-cation interactions on sodium and potassium ion transport within the channel. Graduate and undergraduates students involved in the research will be introduced to modeling an important, natural process by means of model compounds and synthetically tailoring these compounds to examine specific interactions involved in the process. With this award, the Organic and Macromolecular Chemistry Program supports the research and educational activities of Dr. George Gokel of the Department of Molecular Biology and Pharmacology at the Washington University School of Medicine. Dr Gokel will focus his research on the synthesis of macromolecular systems composed of a number of equivalent cyclic subunits connected by molecular spacers that, in toto, are referred to as ion channels. These molecular systems, which mimic naturally occuring biological systems, will be synthetically modified to explore a specific interaction that affects the movement of sodium and potassium ions through the channel. Dr. Gokel's educational activities will involve training graduate and undergraduate students in the syntheses of these model systems, and their characterization as ion conductors.