Synthetic Chemical Models of Ammonium Arene Interactions

本研究项目的重点是分子的设计和合成，这将允许分析阳离子铵离子和芳烃环之间的相互作用。气相（质谱）、溶液相（核磁共振）和固相（x射线晶体学）相结合的分析将对合成化合物进行，将铵离子放置在靠近芳烃环的地方，以确定涉及这种阳离子- π型相互作用的参数。该奖项来自有机和大分子化学项目，支持华盛顿大学分子生物学和药理学系主任George W. Gokel教授的研究。通过模型化合物的设计、合成和研究，Gokel教授正在探索某些氨基酸中发现的带正电基团与其他氨基酸中发现的苯型环之间的潜在相互作用。这种相互作用，虽然在本质上是微妙的，但在决定多肽的结构、性质和功能方面可能共同起着重要的作用。

This research program focuses on the design and synthesis of molecules which will allow analysis of the interactions between cationic ammonium ions and arene rings. A combination of gas-phase (mass spectrometric), solution-phase (NMR), and solid-phase (x-ray crystallographic) analyses will be carried out on synthetic compounds placing ammonium ions in close proximity to arene rings in order to define the parameters involved in this cation-pi type interaction.This award from the Organic and Macromolecular Chemistry Program supports the research of Professor George W. Gokel, of the Department of Molecular Biology and Pharmacology at Washington University. Through the design, synthesis, and study of model compounds, Professor Gokel is exploring the potential interactions between the positively-charged groups found in some amino acids and the benzene-type rings found in other amino acids. Such interactions, while individually subtle in nature, may collectively play a significant role in determining the structure, properties, and function of polypeptides.