The Chemistry and Properties of Chiral Oxazolines

本研究的重点是手性2-恶唑啉立体选择性反应的研究进展。将开展手性恶唑啉、不对称Ullman偶联形成的多环联芳基和合成(7)-螺烯的简单路线的联萘配体的研究。手性酮亚胺将被用作合成环状和非环状α-(季胺)取代酮的中间体。此外，还将探索通向新型手性配体的新路线。通过这一续展奖项，有机和高分子化学项目支持科罗拉多州立大学化学系的艾伯特·I·迈尔斯博士的研究。迈耶斯教授将把他的工作重点放在旨在买得起各种手性物质的项目上。该项目依赖恶唑啉作为制定方法的关键中间体。这项工作在制药行业具有潜在的影响，是研究生培养的丰富领域。

The focus of this research is the development of stereoselective reactions using chiral 2-oxazolines. The study of binaphthyl ligands carrying chiral oxazolines, polycyclic biaryls formed from an asymmetric Ullman coupling and a simple route to (7)-helicenes will be carried out. Chiral ketenimines will be used as intermediates for the production of both cyclic and acyclic alpha-(quaternary) substituted ketones. Also, new routes leading to novel chiral ligands will be explored. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Albert I. Meyers of the Department of Chemistry at Colorado State University. Professor Meyers will focus his work on projects designed to afford a wide variety of chiral substances. The project relies on the use of oxazolines as the key intermediates for the development of the methodology. The work has potential impact in the pharmaceutical industry and is a rich area for the training of graduate students.