Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV?

血液干细胞中的抗 HIV 基因能否防止 HIV 导致的免疫衰竭？

• 批准号: LP100100242
• 负责人: Prof John Murray
• 金额: $ 25.08万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-02-15 至 2013-02-14
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP100100242
• 关键词: anti; HIV; gene; blood; stem

Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV. In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient. The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.

澳大利亚目前约有15 000人感染了艾滋病毒。基因疗法有能力消除与抗逆转录病毒治疗相关的问题，显著降低治疗费用并简化艾滋病毒的治疗。