Purchase of Mass Spectrometric Instrumentation

这项来自化学研究仪器和设施计划的奖项将帮助加州大学洛杉矶分校化学与生物化学系的教职员工获得现代数据系统，以支持两台微质量ZAB-SE质谱仪。这两个数据系统还将连接到加州大学洛杉矶分校化学与生物化学系共享质谱学实验室现有的微质量Autospec仪器的数据系统。该质谱仪将用于一系列化学研究，包括：1)基于碳硼烷衍生亚基的模块阵列的合成；2)新合成方法的开发及其在生物活性天然产物全合成中的应用；3)面内金属富勒烯的合成；4)相互交织的超分子建筑物和含有机械键的互锁分子化合物的自组装；5)二氰基二氨基硫酚和二氰基二亚胺基硫代苯二酮的化学、结构和反应活性的研究。质谱学(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得分子组成的技术。电喷雾技术的加入将MS的范围扩展到蛋白质和核酸的相对分子质量，远远超过了任何其他技术。电喷雾电离与高分辨率相结合的使用提供了质谱学中可用的最新技术。它为化学家提供了表征化合物的最强大的工具之一。在质谱学中获得这种能力对于开展许多化学领域的前沿研究是至关重要的。

This award from the Chemistry Research Instrumentation and Facilities Program will assist faculty in the Department of Chemistry & Biochemistry at the University of California Los Angeles to acquire modern data systems to support two Micromass ZAB-SE mass spectrometers. These two data systems will also be linked to the data system of an existing Micromass Autospec instrument in the UCLA Department of Chemistry & Biochemistry shared mass spectrometry laboratory. The mass spectrometry equipment will be used by the faculty in a number of chemical studies including: 1) the synthesis of modular arrays based on carborane-derived subunits; 2 ) the development of new synthetic methods and their application to the total synthesis of biologically active natural products; 3) the synthesis of endohedral metallofullerenes; 4) self assembly of interwoven supramolecular edifices and interlocked molecular compounds - the so-called catenanes and rotaxanes - containing mechanical bonds; and 5) studies of the chemistry, structure and reactivity of dicyano-diaminothiophenes and dicyano-diiminothiophene quinones.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest technique available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.