Purchase of Mass Spectrometric Instrumentation

这份来自化学研究仪器和设施项目的合同将帮助加州大学洛杉矶分校化学与生物化学系的教员获得现代数据系统，以支持两台Micromass ZAB-SE质谱仪。这两个数据系统也将连接到加州大学洛杉矶分校化学与生物化学系共享质谱实验室现有的Micromass Autospec仪器的数据系统。质谱分析设备将被学院用于许多化学研究，包括：1)基于碳硼烷衍生亚基的模块化阵列的合成；2)新合成方法的发展及其在生物活性天然产物全合成中的应用；3)内源性金属富勒烯的合成；4)相互交织的超分子结构和含有机械键的互锁分子化合物（即所谓的连环烷和轮烷）的自组装；5)研究了双氰-二氨基噻吩和双氰-二亚氨基噻吩醌类化合物的化学性质、结构和反应性。质谱（MS）是一种用于探测内部结构细节和获得大量有机、生物有机和有机金属分子的分子组成的技术。电喷雾技术的加入将质谱的范围扩展到蛋白质和核酸分子量，远远超出任何其他技术。电喷雾电离结合高分辨率提供了质谱分析的最新技术。它为化学家提供了表征化合物的最有力的工具之一。在质谱法中获得这种能力对于化学许多领域的前沿研究的进行是必不可少的。

This award from the Chemistry Research Instrumentation and Facilities Program will assist faculty in the Department of Chemistry & Biochemistry at the University of California Los Angeles to acquire modern data systems to support two Micromass ZAB-SE mass spectrometers. These two data systems will also be linked to the data system of an existing Micromass Autospec instrument in the UCLA Department of Chemistry & Biochemistry shared mass spectrometry laboratory. The mass spectrometry equipment will be used by the faculty in a number of chemical studies including: 1) the synthesis of modular arrays based on carborane-derived subunits; 2 ) the development of new synthetic methods and their application to the total synthesis of biologically active natural products; 3) the synthesis of endohedral metallofullerenes; 4) self assembly of interwoven supramolecular edifices and interlocked molecular compounds - the so-called catenanes and rotaxanes - containing mechanical bonds; and 5) studies of the chemistry, structure and reactivity of dicyano-diaminothiophenes and dicyano-diiminothiophene quinones.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest technique available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.