Purchase of Mass Spectrometric Instrumentation

购买质谱仪器

• 批准号: 9808175
• 负责人: Emil Reisler
• 金额: $ 5.6万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9808175&HistoricalAwards=false
• 关键词: Purchase; Mass; Spectrometric; Instrumentation

This award from the Chemistry Research Instrumentation and Facilities Program will assist faculty in the Department of Chemistry & Biochemistry at the University of California Los Angeles to acquire modern data systems to support two Micromass ZAB-SE mass spectrometers. These two data systems will also be linked to the data system of an existing Micromass Autospec instrument in the UCLA Department of Chemistry & Biochemistry shared mass spectrometry laboratory. The mass spectrometry equipment will be used by the faculty in a number of chemical studies including: 1) the synthesis of modular arrays based on carborane-derived subunits; 2 ) the development of new synthetic methods and their application to the total synthesis of biologically active natural products; 3) the synthesis of endohedral metallofullerenes; 4) self assembly of interwoven supramolecular edifices and interlocked molecular compounds - the so-called catenanes and rotaxanes - containing mechanical bonds; and 5) studies of the chemistry, structure and reactivity of dicyano-diaminothiophenes and dicyano-diiminothiophene quinones.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest technique available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.

化学研究仪器和设施计划的这一奖项将帮助加州洛杉矶大学化学生物化学系的教师获得现代数据系统，以支持两台Micromass ZAB-SE质谱仪。 这两个数据系统也将连接到现有的Micromass Autospec仪器的数据系统在加州大学洛杉矶分校化学生物化学系共享质谱实验室。 该学院将利用质谱仪进行多项化学研究，包括：1）基于碳硼烷衍生亚基的模块阵列的合成; 2）开发新的合成方法及其在生物活性天然产物全合成中的应用; 3）内嵌金属富勒烯的合成; 4）相互交织的超分子结构和互锁的分子化合物（所谓的索烷和轮烷）的自组装，含有机械键; 5）化学研究，二氰基-二氨基噻吩和二氰基-二亚氨基噻吩醌结构和反应性。质谱法（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。电喷雾技术的加入将质谱的范围扩展到蛋白质和核酸分子量，远远超过任何其他技术。电喷雾电离与高分辨率结合使用提供了质谱分析中可用的最新技术。它为化学家提供了表征化合物的最强大的工具之一。在质谱分析中获得这种能力对于许多化学领域的前沿研究至关重要。