Chemical and Spectroscopic Studies of Nitrenium Ions and Related Species

支持马里兰州大学帕克分校的丹尼尔法尔维博士 NSF有机和高分子化学计划。 研究 涉及氮离子（NR 2+）的光谱和反应性研究， 它们是碳离子的氮类似物。 它们包含一对 可以排列成单重态或三重态自旋的非键电子 每个国家都有自己独特的反应模式， 化学致癌作用的中间体。 亲核反应 DNA中的鸟嘌呤碱基被认为导致诱变损伤， 会导致癌症 研究的重点是氮离子的结构和反应性- 反应性中间体可能参与引起某些类型的 癌 这项工作将是感兴趣的其他工作在有关 领域，并将提供宝贵的培训，研究生 对有机化学或肿瘤学感兴趣。

Dr. Daniel Falvey at the University of Maryland - College Park is supported by the NSF Organic and Macromolecular Chemistry Program. The research involves spectroscopic and reactivity studies of nitrenium ions (NR2+), which are nitrogen analogues of carbonium ions. They contain a pair of nonbonding electrons which may align to give singlet or triplet spin states, each with its own distinct reactivity pattern, and may be intermediates in chemical carcinogenesis. Reactions with nucleophilic guanine bases in DNA are believed to result in mutagenic lesions which can lead to cancer. The research focuses on the structure and reactivity of nitrenium ions - reactive intermediates which may be involved in causing some kinds of cancer. The work will be of interest to others working in related fields, and will provide valuable training to graduate students interested in careers in organic chemistry or oncology.