Chemical and Spectroscopic Studies of Nitrenium Ions and Related Species

氮离子及相关物质的化学和光谱研究

• 批准号: 9810111
• 负责人: Daniel Falvey
• 金额: $ 32.11万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9810111&HistoricalAwards=false
• 关键词: Chemical; Spectroscopic; Studies; Nitrenium; Ions

Dr. Daniel Falvey at the University of Maryland - College Park is supported by the NSF Organic and Macromolecular Chemistry Program. The research involves spectroscopic and reactivity studies of nitrenium ions (NR2+), which are nitrogen analogues of carbonium ions. They contain a pair of nonbonding electrons which may align to give singlet or triplet spin states, each with its own distinct reactivity pattern, and may be intermediates in chemical carcinogenesis. Reactions with nucleophilic guanine bases in DNA are believed to result in mutagenic lesions which can lead to cancer. The research focuses on the structure and reactivity of nitrenium ions - reactive intermediates which may be involved in causing some kinds of cancer. The work will be of interest to others working in related fields, and will provide valuable training to graduate students interested in careers in organic chemistry or oncology.

马里兰大学帕克分校的丹尼尔·法尔维博士得到了美国国家科学基金会有机和大分子化学项目的支持。该研究涉及氮离子（NR2+）的光谱和反应性研究，氮离子是碳离子的氮类似物。它们含有一对非成键电子，可以排列成单线态或三重态自旋，每一种都有自己独特的反应模式，可能是化学致癌的中间产物。与DNA中的亲核鸟嘌呤碱基的反应被认为会导致致突变病变，从而导致癌症。对可能与某些癌症发生有关的反应性中间体——氮离子的结构和反应性进行了研究。这项工作将对其他在相关领域工作的人感兴趣，并将为对有机化学或肿瘤学职业感兴趣的研究生提供有价值的培训。