Chemical and Spectroscopic Studies of Nitrenium Ions and Related Species

获得此奖项后，法尔维教授将继续他在氮离子和相关缺电子氮物种的化学和光谱研究方面的工作。各种实验技术将被用来阐明氮离子的化学和物理性质。本文将对芳基氮离子的化学性质进行详细的研究。芳基氮离子在生物系统中是通过酶催化芳香胺代谢产生的。这些氮离子具有亲电性，因此反应性很强，因此在生物体中产生这些离子被认为具有诱变和/或致癌作用。芳基氮离子也涉及作为中间体在合成聚苯胺，导电聚合物。将利用苯胺氧化生成氮离子，并研究其与多种富电子芳烃的反应。法尔维教授和他的团队还将致力于制备和研究基态三态氮离子，因为理论预测它们将具有与本提案第一部分概述的基态单线态氮离子不同的化学反应性。通过这个奖项，有机和大分子化学项目支持了马里兰大学帕克分校化学系丹尼尔·e·法尔维博士的研究。法尔维博士将致力于生成和研究一类被称为氮离子的活性分子。这些分子含有一个缺乏电子的、因此具有化学活性的氮原子，作为其分子结构的一部分。氮离子在生物系统中是通过酶催化芳香胺代谢产生的。这些物质在生物体中的产生被认为具有诱变性和/或致癌性。在聚苯胺（一种导电聚合物）的合成过程中，氮离子也作为中间体存在。彻底了解这些物质是如何产生的以及它们是如何反应的，将有助于更好地理解上述两个过程中涉及的基本化学。在此工作过程中训练的学生将获得特种化学品工业和制药工业所需的技能。

With this award Professor Falvey will continue his work on the chemical and spectroscopic studies of nitrenium ions and related electron deficient nitrogen species. A variety of experimental techniques will be used to elucidate the chemical and physical properties of nitrenium ions. The chemistry of aryl nitrenium ions will be studied in detail in the course of this work. Aryl nitrenium ions are generated in biological systems through enzyme catalyzed metabolism of aromatic amines. These nitrenium ions are electrophilic and hence very reactive so the production of these species in living organisms is believed to be mutagenic and/or carcinogenic. Aryl nitrenium ions are also implicated as intermediates in the synthesis of polyanilines, a conducting polymer. Aniline oxidation will be used to generate nitrenium ions and their reactions with a variety of electron rich arenes will be studied. Professor Falvey and his group will also work to prepare and study ground state triplet nitrenium ions since theory predicts they will have different chemical reactivities than the ground state singlet nitrenium ions outlined in the first part of this proposal.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Daniel E. Falvey of the Department of Chemistry at the University of Maryland, College Park. Dr. Falvey will work on the generation and study of a family of reactive molecules known as nitrenium ions. These molecules contain an electron deficient and hence chemically reactive nitrogen atom as part of their molecular structure. Nitrenium ions are generated in biological systems through enzyme catalyzed metabolism of aromatic amines. The production of these species in living organisms is believed to be mutagenic and/or carcinogenic. Nitrenium ions are also implicated as intermediates in the synthesis of polyanilines, a conducting polymer. A thorough understanding of how these species are generated and how they react should contribute to a better understanding of the fundamental chemistry involved in both of the processes outlined above. Students trained during the course of this work will gain skills needed by the speciality chemicals industry and the pharmaceutical industry.