Chemical and Spectroscopic Studies of Nitrenium Ions and Related Species

氮离子及相关物质的化学和光谱研究

• 批准号: 0203142
• 负责人: Daniel Falvey
• 金额: $ 37万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0203142&HistoricalAwards=false
• 关键词: Chemical; Spectroscopic; Studies; Nitrenium; Ions

With this award Professor Falvey will continue his work on the chemical and spectroscopic studies of nitrenium ions and related electron deficient nitrogen species. A variety of experimental techniques will be used to elucidate the chemical and physical properties of nitrenium ions. The chemistry of aryl nitrenium ions will be studied in detail in the course of this work. Aryl nitrenium ions are generated in biological systems through enzyme catalyzed metabolism of aromatic amines. These nitrenium ions are electrophilic and hence very reactive so the production of these species in living organisms is believed to be mutagenic and/or carcinogenic. Aryl nitrenium ions are also implicated as intermediates in the synthesis of polyanilines, a conducting polymer. Aniline oxidation will be used to generate nitrenium ions and their reactions with a variety of electron rich arenes will be studied. Professor Falvey and his group will also work to prepare and study ground state triplet nitrenium ions since theory predicts they will have different chemical reactivities than the ground state singlet nitrenium ions outlined in the first part of this proposal.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Daniel E. Falvey of the Department of Chemistry at the University of Maryland, College Park. Dr. Falvey will work on the generation and study of a family of reactive molecules known as nitrenium ions. These molecules contain an electron deficient and hence chemically reactive nitrogen atom as part of their molecular structure. Nitrenium ions are generated in biological systems through enzyme catalyzed metabolism of aromatic amines. The production of these species in living organisms is believed to be mutagenic and/or carcinogenic. Nitrenium ions are also implicated as intermediates in the synthesis of polyanilines, a conducting polymer. A thorough understanding of how these species are generated and how they react should contribute to a better understanding of the fundamental chemistry involved in both of the processes outlined above. Students trained during the course of this work will gain skills needed by the speciality chemicals industry and the pharmaceutical industry.

获得这一奖项后，法尔维教授将继续他在硝离子和相关缺电子氮物种的化学和光谱研究方面的工作。将使用各种实验技术来阐明硝离子的化学和物理性质。在这项工作中，将详细研究芳基硝离子的化学。芳基硝离子在生物系统中是通过酶催化芳香胺的代谢而产生的。这些硝离子是亲电性的，因此非常活跃，所以这些物种在活体中的产生被认为是诱变和/或致癌的。芳基硝离子也被认为是合成导电聚合物聚苯胺的中间体。将利用苯胺氧化生成硝离子，并研究它们与各种富含电子芳烃的反应。法尔维教授和他的团队还将致力于制备和研究基态三重态镍离子，因为理论预测它们的化学反应活性将不同于本提案第一部分中概述的基态单态镍离子。有了这个奖项，有机化学和高分子化学计划将支持马里兰大学帕克分校化学系的丹尼尔·E·福尔维博士的研究。法尔维博士将致力于生成和研究一类被称为硝离子的活性分子。作为分子结构的一部分，这些分子含有一个缺电子的、因此具有化学反应活性的氮原子。在生物系统中，硝离子是通过酶催化芳香胺的代谢而产生的。这些物种在活体中的产生被认为是诱变和/或致癌的。在导电聚合物聚苯胺的合成过程中，镍离子也是中间体。彻底了解这些物种是如何产生的以及它们是如何反应的，应该有助于更好地理解上述两个过程所涉及的基本化学。在这项工作过程中培训的学生将获得特殊化学品行业和制药行业所需的技能。