Chemical and Spectroscopic Studies of Nitrenium Ions and Related Species

有了这个奖项，法尔维教授将继续他的工作，对氮离子和相关的缺电子氮物种的化学和光谱研究。 各种实验技术将被用来阐明氮离子的化学和物理性质。 芳基氮鎓离子的化学将在这项工作的过程中详细研究。 芳基氮鎓离子在生物系统中通过芳香胺的酶催化代谢产生。 这些氮离子是亲电子的，因此非常活泼，因此在活生物体中产生这些物质被认为是致突变和/或致癌的。 芳基氮鎓离子也被认为是合成聚苯胺（一种导电聚合物）的中间体。 苯胺氧化将被用来产生氮离子，并将研究它们与各种富电子芳烃的反应。 Falvey教授和他的团队还将致力于制备和研究基态三重态氮鎓离子，因为理论预测它们将具有与本提案第一部分中概述的基态单重态氮鎓离子不同的化学反应性。有了这个奖项，有机和大分子化学计划将支持丹尼尔E.法尔维说，他是马里兰州大学帕克分校化学系的教授。 Falvey博士将致力于生成和研究一系列被称为氮离子的反应分子。 这些分子含有一个缺电子的，因此具有化学活性的氮原子作为其分子结构的一部分。 氮鎓离子在生物系统中通过芳香胺的酶催化代谢产生。 在活生物体中产生这些物质被认为具有致突变性和/或致癌性。 氮鎓离子也是合成聚苯胺（一种导电聚合物）的中间体。 彻底了解这些物质是如何产生的，以及它们是如何反应的，应该有助于更好地理解上述两个过程中所涉及的基本化学。 在这项工作的过程中接受培训的学生将获得特殊化学品行业和制药行业所需的技能。

With this award Professor Falvey will continue his work on the chemical and spectroscopic studies of nitrenium ions and related electron deficient nitrogen species. A variety of experimental techniques will be used to elucidate the chemical and physical properties of nitrenium ions. The chemistry of aryl nitrenium ions will be studied in detail in the course of this work. Aryl nitrenium ions are generated in biological systems through enzyme catalyzed metabolism of aromatic amines. These nitrenium ions are electrophilic and hence very reactive so the production of these species in living organisms is believed to be mutagenic and/or carcinogenic. Aryl nitrenium ions are also implicated as intermediates in the synthesis of polyanilines, a conducting polymer. Aniline oxidation will be used to generate nitrenium ions and their reactions with a variety of electron rich arenes will be studied. Professor Falvey and his group will also work to prepare and study ground state triplet nitrenium ions since theory predicts they will have different chemical reactivities than the ground state singlet nitrenium ions outlined in the first part of this proposal.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Daniel E. Falvey of the Department of Chemistry at the University of Maryland, College Park. Dr. Falvey will work on the generation and study of a family of reactive molecules known as nitrenium ions. These molecules contain an electron deficient and hence chemically reactive nitrogen atom as part of their molecular structure. Nitrenium ions are generated in biological systems through enzyme catalyzed metabolism of aromatic amines. The production of these species in living organisms is believed to be mutagenic and/or carcinogenic. Nitrenium ions are also implicated as intermediates in the synthesis of polyanilines, a conducting polymer. A thorough understanding of how these species are generated and how they react should contribute to a better understanding of the fundamental chemistry involved in both of the processes outlined above. Students trained during the course of this work will gain skills needed by the speciality chemicals industry and the pharmaceutical industry.