Beta-Cyclodextrin Reaction Cavities-Solid State Reactions- from Disordered Crystals to Added Insight into Reaction - Mechanisms

β-环糊精反应腔 - 固态反应 - 从无序晶体到增加对反应的洞察 - 机制

• 批准号: 9812146
• 负责人: John Stezowski
• 金额: $ 32.2万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9812146&HistoricalAwards=false
• 关键词: Beta; Cyclodextrin; Reaction; Cavities; Solid

The proposed research involves mechanistic studies of the photolysis of organic guest molecules in beta-cyclodextrin hosts. Reaction rates and products will be determined using a combination of x-ray crystallography, solid-state NMR, and GC/MS.With this New award, the Organic and Macromolecular Chemistry Program supports the collaborative research of Drs. John J. Stezowski and Gerard S. Harbison at the University of Nebraska-Lincoln. The research focuses on understanding the factors which determine the distribution of products formed in the solid state when molecules, known to react when they absorb ultraviolet light in solution, are exposed to radiation in a beta-cyclodextrin cavity in a solid matrix. The work is expected to provide important insights into how organic reactions take place in solids, and how they differ from reactions in solution. It should also provide valuable chemical training for both graduate and undergraduate students.

拟议的研究涉及β-环糊精主体中有机客体分子光解的机理研究。 反应速率和产物将结合使用 X 射线晶体学、固态 NMR 和 GC/MS 来确定。通过这一新奖项，有机和高分子化学项目支持 Drs. 的合作研究。内布拉斯加大学林肯分校的约翰·J·斯特佐斯基 (John J. Stezowski) 和杰拉德·S·哈比森 (Gerard S. Harbison)。 该研究的重点是了解当分子暴露在固体基质中的β-环糊精空腔中的辐射下时，确定在固态中形成的产物分布的因素，这些分子在溶液中吸收紫外线时会发生反应。 这项工作预计将为有机反应如何在固体中发生以及它们与溶液中的反应有何不同提供重要见解。 它还应该为研究生和本科生提供有价值的化学培训。