U.S.-France Cooperative Research: Development of Improved Methods for High Resolution Crystallographic Refinement

美法合作研究：开发高分辨率晶体细化改进方法

• 批准号: 9815595
• 负责人: L. Mario Amzel
• 金额: $ 1.25万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-15 至 2003-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9815595&HistoricalAwards=false
• 关键词: U.S.; France; Cooperative; Research; Development

9815595AmzelThis three-year award will support US-France collaborative research between L. Mario Amzel of Johns Hopkins University's School of Medicine and Alberto Podjarny of the University Louis Pasteur in Strasbourg, France. The objective of their research is to develop methods (algorithms) and computational tools for the refinement, analysis, and modeling of protein structures that are obtained by using very high-resolution X-ray crystallographic data. These new tools are needed to take advantage of high intensity synchrotron radiation sources and very sensitive detectors. These advanced facilities and equipment have created opportunities to study biomolecules more accurately than ever. The computations will be performed in cooperation with Dr. Raul Cachau of the National Cancer Institute's Biomedical Supercomputer Center.Dr. Amzel brings to this collaboration expertise in crystallographic structure determination and refinement. This is complemented by the expertise of the French investigator, who is a computational crystallographer. Their joint effort will advance the ability to refine crystal structures through the development of new computational tools.

9815595Amzel 这个为期三年的奖项将支持约翰·霍普金斯大学医学院的 L. Mario Amzel 和法国斯特拉斯堡路易斯巴斯德大学的 Alberto Podjarny 之间的美法合作研究。 他们研究的目标是开发方法（算法）和计算工具，用于对通过使用极高分辨率 X 射线晶体学数据获得的蛋白质结构进行细化、分析和建模。 需要这些新工具来利用高强度同步加速器辐射源和非常灵敏的探测器。这些先进的设施和设备为比以往更准确地研究生物分子创造了机会。 该计算将与美国国家癌症研究所生物医学超级计算机中心的 Raul Cachau 博士合作进行。 Amzel 为此次合作带来了晶体结构测定和细化方面的专业知识。 法国研究人员（计算晶体学家）的专业知识对此进行了补充。 他们的共同努力将通过开发新的计算工具来提高细化晶体结构的能力。