U.S.-France Cooperative Research: Development of Improved Methods for High Resolution Crystallographic Refinement

这个为期三年的奖项将支持约翰霍普金斯大学医学院的L. Mario Amzel和法国斯特拉斯堡路易斯巴斯德大学的Alberto Podjarny的美法合作研究。他们的研究目标是开发方法（算法）和计算工具，用于通过使用非常高分辨率的x射线晶体学数据获得的蛋白质结构的细化、分析和建模。这些新工具需要利用高强度同步辐射源和非常敏感的探测器。这些先进的设施和设备创造了比以往更准确地研究生物分子的机会。计算将与国家癌症研究所生物医学超级计算机中心的Raul Cachau博士合作进行。Amzel为此次合作带来了晶体结构测定和细化方面的专业知识。这是由法国研究者的专业知识补充，他是一名计算晶体学家。他们的共同努力将通过开发新的计算工具来提高改进晶体结构的能力。

9815595AmzelThis three-year award will support US-France collaborative research between L. Mario Amzel of Johns Hopkins University's School of Medicine and Alberto Podjarny of the University Louis Pasteur in Strasbourg, France. The objective of their research is to develop methods (algorithms) and computational tools for the refinement, analysis, and modeling of protein structures that are obtained by using very high-resolution X-ray crystallographic data. These new tools are needed to take advantage of high intensity synchrotron radiation sources and very sensitive detectors. These advanced facilities and equipment have created opportunities to study biomolecules more accurately than ever. The computations will be performed in cooperation with Dr. Raul Cachau of the National Cancer Institute's Biomedical Supercomputer Center.Dr. Amzel brings to this collaboration expertise in crystallographic structure determination and refinement. This is complemented by the expertise of the French investigator, who is a computational crystallographer. Their joint effort will advance the ability to refine crystal structures through the development of new computational tools.