The Control of Cell Division in the Root Meristem

根分生组织细胞分裂的控制

• 批准号: 9817132
• 负责人: Tobias Baskin
• 金额: $ 24.6万
• 依托单位: University of Missouri-Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9817132&HistoricalAwards=false
• 关键词: Control; Cell; Division; Root; Meristem

Understanding the development of organisms entails understanding how cell division is controlled. While a great deal has been learned about the regulation of the cell cycle, much less is known about how a developing organism controls the rate and location of cell division activity. This project aims to deepen our knowledge of how a growing plant organ controls the spatial distribution of cell division, by using as a model the root meristem of Arabidopsis thaliana. The project will test hypotheses about the regulation of cell division, specifically addressing how cells decide to stop dividing. Do cells stop dividing when they start expanding too rapidly or when their volume becomes too great? Although this project uses plants as experimental material, much of what is known about how cell division is controlled in plants appears to be true also for animals. When animal cells fail to stop dividing, the result can be cancer; thus the findings from this project may apply not only to optimizing plant growth for agriculture but might ultimately apply to minimizing the threat of cancer.

理解生物体的发育需要理解细胞分裂是如何被控制的。虽然我们对细胞周期的调节已经了解了很多，但对于发育中的生物体如何控制细胞分裂活动的速度和位置，我们所知甚少。本项目旨在通过拟南芥的根分生组织作为模型，加深我们对生长中的植物器官如何控制细胞分裂的空间分布的认识。该项目将测试关于细胞分裂调节的假设，特别是研究细胞如何决定停止分裂。当细胞扩张过快或体积过大时，它们会停止分裂吗？虽然这个项目使用植物作为实验材料，但是关于植物如何控制细胞分裂的许多已知知识似乎也适用于动物。当动物细胞不能停止分裂时，结果可能是癌症；因此，这个项目的发现可能不仅适用于优化农业植物生长，而且最终可能适用于减少癌症的威胁。