Symposium: Organismal, Ecological and2Evolutionary Significance of Heat Shock Proteins and the Heat Shock Response;, Colorado; January 6-10, 1999

霍夫曼98-17200生物利用热休克反应来保护自己免受众多环境压力的影响，其中包括增加热休克蛋白(HSP)的丰度。其中一些热休克蛋白作为分子伴侣，允许蛋白质保留蛋白质功能所需的三维结构。在热休克蛋白的细胞和分子生物学方面已经做了大量的工作。本次研讨会将评估热休克蛋白在自然界中的作用，以及热休克蛋白的进化和热休克反应。一些发言者将讨论热休克蛋白在生物体对高温耐受性、冬眠、对寄生的反应以及在正常发育和衰老过程中的作用。其他与会者将强调热休克蛋白在自然界生物中的表达，热休克蛋白表达的成本和收益以及热休克蛋白基因的进化。研讨会将促进正在研究这一重要生物学问题的不同学科的科学家之间的讨论、互动和合作。研讨会将回顾关于生物生物学中热休克蛋白的知识现状，并突出尚未回答的问题。通过这样做，它将决定未来的研究方向。

Hofmann 98-17200 Organisms protect themselves from numerous environmental stresses using the heat shock response, which includes a increase in the abundance of heat shock proteins (HSPs). Some of these HSPs serve as molecular chaparones to allow proteins to retain the 3-dimensional structure necessary for protein function. Much work has been done on the cell and molecular biology of HSPs. This symposium will asses the role of HSPs in nature and the evolution of HSPs and the heat shock response. Some speakers will address the role of HSPs in organismal tolerance to heat, hibernation, response to parasitism and in normal development and aging processes. Other participants will emphasize the expression of HSPs in organisms in nature, the cost and benefits of HSP expression and the evolution of HSP genes. The symposium will facilitate discussion, interaction and collaboration among scientist in diverse disciplines who are studying this important biological issue. The symposium will review the current state of knowledge about HSPs in organismal biology and highlight unanswered questions. By doing so, it will determine future research directions.