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Symposium: Organismal, Ecological and2Evolutionary Significance of Heat Shock Proteins and the Heat Shock Response;, Colorado; January 6-10, 1999

研讨会：热休克蛋白和热休克反应的有机、生态和进化意义；科罗拉多州；

基本信息

批准号：
9817200
负责人：
Gretchen Hofmann
金额：
$ 0.6万
依托单位：
University of California-Berkeley
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
1998
资助国家：
美国
起止时间：
1998-12-15 至 1999-11-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9817200&HistoricalAwards=false
关键词：
Symposium Organismal Ecological and2Evolutionary Significance

项目摘要

Hofmann 98-17200 Organisms protect themselves from numerous environmental stresses using the heat shock response, which includes a increase in the abundance of heat shock proteins (HSPs). Some of these HSPs serve as molecular chaparones to allow proteins to retain the 3-dimensional structure necessary for protein function. Much work has been done on the cell and molecular biology of HSPs. This symposium will asses the role of HSPs in nature and the evolution of HSPs and the heat shock response. Some speakers will address the role of HSPs in organismal tolerance to heat, hibernation, response to parasitism and in normal development and aging processes. Other participants will emphasize the expression of HSPs in organisms in nature, the cost and benefits of HSP expression and the evolution of HSP genes. The symposium will facilitate discussion, interaction and collaboration among scientist in diverse disciplines who are studying this important biological issue. The symposium will review the current state of knowledge about HSPs in organismal biology and highlight unanswered questions. By doing so, it will determine future research directions.

霍夫曼98-17200 生物体利用热休克反应来保护自己免受许多环境压力的影响，其中包括热休克蛋白（HSP）丰度的增加。这些热休克蛋白中的一些充当分子伴侣，以允许蛋白质保留蛋白质功能所必需的三维结构。热休克蛋白的细胞和分子生物学研究已取得了很大进展。本次研讨会将评估热休克蛋白在自然界中的作用，热休克蛋白的进化和热休克反应。一些演讲者将讨论热休克蛋白在生物体对热的耐受性，冬眠，对寄生虫的反应以及正常发育和衰老过程中的作用。其他与会者将强调热休克蛋白在自然界中的生物体中的表达，热休克蛋白表达的成本和效益以及热休克蛋白基因的进化。研讨会将促进正在研究这一重要生物问题的不同学科的科学家之间的讨论、互动和合作。研讨会将回顾目前关于热休克蛋白在生物学中的知识状况，并强调尚未回答的问题。通过这样做，它将决定未来的研究方向。