Mechanisms of Endocyclic Atom Transfers

通过这个续展奖项，有机和高分子化学项目支持了伊利诺伊大学香槟分校化学系的Peter Beak博士的工作。这项研究旨在将早期关于内环原子转移反应的工作扩展到包括氟、氯、溴、氧和硫的转移。所使用的方法包括：1)遵循双标记反应的动力学，2)核磁共振自旋饱和转移，3)分子内竞争转移，4)瞬时双标记物种和替代分子间报告分子的形成。预计所获得的信息将增加我们对原子转移反应所涉及的反应轮廓的了解，将具有理论意义，并将对合成，特别是在使光学活性化合物用于药物方面具有实际意义。参与这项工作的研究生将在有机合成、产品表征以及动力学和机理方面获得宝贵的经验，目前制药行业对这些领域的需求很大。

With this renewal award the Organic and macromolecular Chemistry Program supports the work of Dr. Peter Beak in the Department of Chemistry at the University of Illinois at Urbana-Champaign. The research aims to extend the earlier work on endocyclic atom transfer reactions to include transfers of fluorine, chlorine, bromine, oxygen, and sulfur. Methods to be used include: 1) following kinetics of the reactions with double labelling, 2) NMR spin saturation transfer, 3) competitive intramolecular transfers, and 4) the formation of transient double labelled species and surrogate intermolecular reporter molecules.It is anticipated that the information obtained in the proposed studies will increase our understanding of the reaction profiles involved in atom transfer reactions, will be of theoretical interest, and will have practical consequences for synthesis, especially in making optically active compounds useful for pharmaceuticals. Graduate students involved in the work will gain valuable experience in organic synthesis, product characterization, and kinetics and mechanism, currently in great demand in the pharmaceutical industry.