Mechanisms of Endocyclic Atom Transfers

有了这个更新奖的有机和大分子化学计划支持博士的工作。 该研究旨在将早期的内环原子转移反应扩展到包括氟，氯，溴，氧和硫的转移。 使用的方法包括：1）遵循双标记反应的动力学，2）NMR自旋饱和转移，3）竞争性分子内转移，以及4）瞬时双标记物质和替代分子间报告分子的形成。预计在拟议的研究中获得的信息将增加我们对原子转移反应中涉及的反应曲线的理解，将具有理论意义，并且将对合成，特别是在制备可用于药物的光学活性化合物中具有实际意义。 参与这项工作的研究生将获得有机合成，产品表征，动力学和机理方面的宝贵经验，目前在制药工业中需求量很大。

With this renewal award the Organic and macromolecular Chemistry Program supports the work of Dr. Peter Beak in the Department of Chemistry at the University of Illinois at Urbana-Champaign. The research aims to extend the earlier work on endocyclic atom transfer reactions to include transfers of fluorine, chlorine, bromine, oxygen, and sulfur. Methods to be used include: 1) following kinetics of the reactions with double labelling, 2) NMR spin saturation transfer, 3) competitive intramolecular transfers, and 4) the formation of transient double labelled species and surrogate intermolecular reporter molecules.It is anticipated that the information obtained in the proposed studies will increase our understanding of the reaction profiles involved in atom transfer reactions, will be of theoretical interest, and will have practical consequences for synthesis, especially in making optically active compounds useful for pharmaceuticals. Graduate students involved in the work will gain valuable experience in organic synthesis, product characterization, and kinetics and mechanism, currently in great demand in the pharmaceutical industry.