Determination of Transition Structure Geometries for Reactions at Nonstereogenic Atoms

非立体原子反应的过渡结构几何形状的测定

• 批准号: 9526355
• 负责人: Peter Beak
• 金额: $ 46.4万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9526355&HistoricalAwards=false
• 关键词: Determination; Transition; Structure; Geometries; Reactions

With funding from the Organic Dynamics Program, Professor Beak will elaborate the dynamic behavior of organolithium in organic transformations. The endocyclic restriction test methodology will be applied to a myriad of organic processes of importance to organic synthesis. By the use of this methodology, a better understanding of the transition state trajectories shall result. Thus, the improved use of this popular reagent should makes its application more efficient and predictable. Information about the ground states of a given reaction is relatively easily obtained. However, the same clear understanding of the transition states of reactions involving organolithium reagents is not known. Thus, this investigation will attempt to elaborate these states in order to help users of these reagents to employ them more efficiently. Moreover, new and basic physical organic methodologies shall be validated.

在有机动力学项目的资助下，Beak 教授将详细阐述有机锂在有机转化中的动态行为。环内限制性测试方法将应用于对有机合成重要的多种有机过程。通过使用这种方法，可以更好地理解过渡状态轨迹。因此，改进这种流行试剂的使用应该使其应用更加高效和可预测。 有关给定反应的基态的信息相对容易获得。然而，对涉及有机锂试剂的反应的过渡态的同样清晰的理解尚不清楚。因此，本研究将尝试详细阐述这些状态，以帮助这些试剂的使用者更有效地使用它们。此外，应验证新的基本物理有机方法。