Using a Permanent Magnet System to Provide 1H and 13C FT-NMR Instrumentation in the Undergraduate Curriculum

在本科课程中使用永磁系统提供 1H 和 13C FT-NMR 仪器

• 批准号: 9851253
• 负责人: Paul Ogren
• 金额: $ 2.4万
• 依托单位: Earlham College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9851253&HistoricalAwards=false
• 关键词: Using; Permanent; Magnet; System; Provide

The purpose of this project is to provide our students with laboratory experience in modern Fourier transform-based multinuclear 1H and 13C nuclear magnetic resonance applications. The selected instrument uses an existing 1.4 Tesla permanent magnet augmented with FT probes shims and software to permit student operation with minimal training. This will allow students to begin to use the instrumentation early in a sophomore organic laboratory course. Chemistry majors and minors will continue to work with NMR applications in later analytical, physical, and advanced organic courses. They will become familiar not only with routine applications for simple structural identifications, but with advanced applications such as COSY, inversion/recovery measurements of T1, temperature-dependent exchange kinetics, and saturation transfer studies. Since this is not a high-field magnet system, the sensitivity and resolution will not match that of a typical superconducting NMR. In an educational setting, these disadvantages are offset by the fact that the proposed system is relatively easy to Maintain, the purchase and operating costs are much lower, and the versatility of the probe and software will still permit students to set up and run sophisticated range of experiments.

本项目的目的是为学生提供基于现代傅里叶变换的多核1H和13C核磁共振应用的实验室经验。所选仪器使用现有的1.4特斯拉永磁体，增强FT探针垫片和软件，允许学生在最少的培训下操作。这将允许学生在二年级有机实验课程的早期就开始使用仪器。化学专业的学生和辅修学生将在以后的分析、物理和高级有机课程中继续使用核磁共振应用。他们将不仅熟悉简单结构鉴定的常规应用，而且熟悉诸如COSY， T1反演/恢复测量，温度依赖交换动力学和饱和转移研究等高级应用。由于这不是一个高场磁体系统，灵敏度和分辨率将无法与典型的超导核磁共振相匹配。在教育环境中，这些缺点被所提出的系统相对容易维护的事实所抵消，购买和操作成本要低得多，并且探针和软件的多功能性仍然允许学生设置和运行复杂的实验范围。