GOALI: Selectivity Crystallization of Molecules on Solid Surfaces Using Engineered Self-Assembled Monolayers as Nanotemplates

GOALI：使用工程自组装单分子层作为纳米模板在固体表面上选择性结晶分子

• 批准号: 9871798
• 负责人: Alexander Couzis
• 金额: $ 45万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2002-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9871798&HistoricalAwards=false
• 关键词: GOALI; Selectivity; Crystallization; Molecules; Solid

ABSTRACT CTS-9871798 A. Couzis/CUNY This research is a joint collaboration between the Department of Chemical Engineering at the City College and the Central Research and Development Division of DuPont. The objective of the research is to design solid surface nanotemplates for the heterogeneous crystallization as seeds of one form of a crystalline material which can exist in several polymorphic forms. These polymorph specific seeds are then used to control the selective crystallization in a bulk industrial crystallizer. The approach employs using self assembled silane or organosulfur monolayers which covalently link to solid supports to functionalize surfaces with chemical moities. The moities are selected in such a way that the surface mimics a crystalline face of the desired polymorph. In this way this face nulceates on the surface, and the mature crystal of the desired polymorph grows. Two systems will be studied, the inorganic polymorphs calcite and vaterite of calcium carbonate, and the alpha and gamma forms of the amino acid glycine. In each of these systems, templates will be constructed for selective crystallization. The research addresses Dupont's requirements for selective polymorphic crystallization in their drug and agrochemical industries, and academically contributes to the development of molecular engineering designs for tailoring of surfaces. The engineered nanotemplates developed under this research effort, will be utilized in the design, construction, and testing at DuPont of a device to fabricate seeds. This research effort there fore represents a directed use of nanostructures.

摘要cts-9871798 a。这项研究是由城市学院化学工程系和杜邦公司中央研发部门联合合作完成的。本研究的目的是设计用于非均相结晶的固体表面纳米模板，作为一种晶体材料的种子，这种晶体材料可以以多种多晶形式存在。这些多晶型特异性种子然后用于控制散装工业结晶器中的选择性结晶。该方法采用自组装硅烷或有机硫单分子层，其共价连接到固体载体以使具有化学运动的表面功能化。以这样一种方式选择运动，使表面模拟所需多晶型的结晶面。以这种方式，该面在表面上为零，所需多晶的成熟晶体生长。将研究两种体系，碳酸钙的无机多晶方解石和水晶石，以及氨基酸甘氨酸的α和γ形式。在这些系统中，模板将被构造为选择性结晶。该研究解决了杜邦公司在其药物和农用化学工业中对选择性多晶化结晶的要求，并在学术上促进了分子工程设计的发展，以定制表面。在这项研究成果下开发的工程纳米模板，将用于杜邦制造种子设备的设计、构建和测试。因此，这项研究工作代表了纳米结构的直接使用。