CAREER: Molecular Imprint Polymer Receptor Mimics and Microscale Separations: Harnessing Molecular Recognition for Combinatorial Library Screening

该CAREER奖由俄勒冈州州立大学的Vincent Remcho教授的分析和表面化学计划支持，是分子印迹聚合物技术与微尺度液相分离技术的发展，可用作筛选生物活性分子的复杂混合物的新分析工具。 分子识别将以共价和非共价形式用于开发新的固定相材料。 三环类抗抑郁化合物将成为印迹特异性的目标化合物。 这项工作将进展到新的特异性方法，用于检测过氧化物酶体增殖物激活受体模拟物。 生物分析课程的课程改革形成了这个职业生涯的建议教育组成部分的重点。分子印迹的前提是，一个分子的形状和大小的记忆可以在一个三维结构中创建。 一旦记忆建立起来，它就变成了一种选择性的工具，就像一把钥匙能插入一把锁一样。 在Remcho教授的工作中，通过分子印迹获得的选择性被用于从复杂混合物中分离目标化合物。

This CAREER award supported by the Analytical and Surface Chemistry Program, by Professor Vincent Remcho of Oregon State University is the development of molecular imprint polymer technology with microscale liquid phase separation techniques to be used as a new analytical tool in the screening of complex mixtures of biologically active molecules for specific activity. Molecular recognition will be used in both covalent and noncovalent formats for the development of new stationary phase materials. Tricyclic antidepressant compounds will be the target compounds for imprinting specificity. The work will progress to novel specifc methods for the detection of PPAR mimics. Bioanalytical course curricular reform forms the focus of the educational component of this CAREER proposal.The premise of molecular imprinting is that a memory of a molecule's shape and size can be created in a three dimensional structure. Once that memory is established, it becomes a selective tool, much as a key fits into a lock. In the case of Professor Remcho's work, the selectivity gained through molecular imprinting is used to advantage in separations of targeted compounds from a complex mixture.