CAREER: Molecular Imprint Polymer Receptor Mimics and Microscale Separations: Harnessing Molecular Recognition for Combinatorial Library Screening

这项职业奖项由俄勒冈州立大学的文森特·雷姆乔教授支持，由分析和表面化学计划支持，是分子印迹聚合物技术的发展，该技术具有微型液体相分离技术，可用作筛选具有特定活性的生物活性分子复杂混合物的新分析工具。分子识别将在共价和非共价两种形式下用于开发新的固定相材料。三环类抗抑郁化合物将成为印迹专一性的目标化合物。这项工作将向检测PPAR模拟物的新的特异性方法迈进。生物分析课程课程改革是这项职业计划的教育部分的重点。分子印迹的前提是可以在三维结构中创建对分子形状和大小的记忆。一旦建立了记忆，它就成了一种选择性的工具，就像钥匙可以放进锁里一样。在Remcho教授的工作中，通过分子印迹获得的选择性被用于从复杂混合物中分离目标化合物。

This CAREER award supported by the Analytical and Surface Chemistry Program, by Professor Vincent Remcho of Oregon State University is the development of molecular imprint polymer technology with microscale liquid phase separation techniques to be used as a new analytical tool in the screening of complex mixtures of biologically active molecules for specific activity. Molecular recognition will be used in both covalent and noncovalent formats for the development of new stationary phase materials. Tricyclic antidepressant compounds will be the target compounds for imprinting specificity. The work will progress to novel specifc methods for the detection of PPAR mimics. Bioanalytical course curricular reform forms the focus of the educational component of this CAREER proposal.The premise of molecular imprinting is that a memory of a molecule's shape and size can be created in a three dimensional structure. Once that memory is established, it becomes a selective tool, much as a key fits into a lock. In the case of Professor Remcho's work, the selectivity gained through molecular imprinting is used to advantage in separations of targeted compounds from a complex mixture.