CAREER: Molecular Imprint Polymer Receptor Mimics and Microscale Separations: Harnessing Molecular Recognition for Combinatorial Library Screening

该职业奖由俄勒冈州立大学的Vincent Remcho教授支持，由分析和表面化学项目支持，是分子印迹聚合物技术与微尺度液相分离技术的发展，作为一种新的分析工具，用于筛选具有特定活性的复杂生物活性分子混合物。分子识别将用于共价和非共价格式的新固定相材料的开发。三环类抗抑郁药物将成为印迹特异性的靶标化合物。这项工作将发展为检测PPAR模拟物的新的特定方法。生物分析课程的课程改革是本职业建议中教育部分的重点。分子印迹的前提是可以在三维结构中创建分子形状和大小的记忆。一旦这种记忆建立起来，它就变成了一种选择性的工具，就像钥匙可以锁住一样。在Remcho教授的工作中，通过分子印迹获得的选择性被用于从复杂混合物中分离目标化合物的优势。

This CAREER award supported by the Analytical and Surface Chemistry Program, by Professor Vincent Remcho of Oregon State University is the development of molecular imprint polymer technology with microscale liquid phase separation techniques to be used as a new analytical tool in the screening of complex mixtures of biologically active molecules for specific activity. Molecular recognition will be used in both covalent and noncovalent formats for the development of new stationary phase materials. Tricyclic antidepressant compounds will be the target compounds for imprinting specificity. The work will progress to novel specifc methods for the detection of PPAR mimics. Bioanalytical course curricular reform forms the focus of the educational component of this CAREER proposal.The premise of molecular imprinting is that a memory of a molecule's shape and size can be created in a three dimensional structure. Once that memory is established, it becomes a selective tool, much as a key fits into a lock. In the case of Professor Remcho's work, the selectivity gained through molecular imprinting is used to advantage in separations of targeted compounds from a complex mixture.