CAREER: Growth Factor Accessibility and the Role of Extracellular Mediators

职业：生长因子的可及性和细胞外介质的作用

• 批准号: 9875626
• 负责人: Kimberly Williams
• 金额: $ 24万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9875626&HistoricalAwards=false
• 关键词: CAREER; Growth; Factor; Accessibility; Role

The overall research objective of this award is to apply engineering principles through mathematical modeling to elucidate important parameters and variables key to the regulation of growth factor transport. This type of analysis should find practical use in deciphering how therapeutics might find access to underlying tissue or be cleared from the blood stream in a timely fashion. The educational objective revolves around the idea that learning relies on effective communication and that team building skills are critical for interdisciplinary work. Methods proposed to meet the educational objective include: (1) the assembly of a biochemical track for undergraduate students interested in cellular engineering; (2) the development of an upper-level undergraduate/graduate course in cellular engineering; (3) the provision of opportunities for women and minorities to investigate what graduate school and cellular engineering involve through undergraduate research; and (4) the incorporation of active learning as well as writing analysis in both classroom instruction and research group meetings to promote deep learning.

本奖项的总体研究目标是运用工程原理，通过数学建模来阐明生长因子转运调控的关键参数和变量。这种类型的分析应该在解释治疗药物如何及时进入底层组织或从血流中清除方面找到实际用途。教育目标围绕着这样一个理念，即学习依赖于有效的沟通，团队建设技能对跨学科工作至关重要。为满足教育目标，提出的方法包括：(1)为对细胞工程感兴趣的本科生装配生化轨道；(2)开设细胞工程的高级本科/研究生课程；(3)为妇女和少数民族提供机会，通过本科生研究来研究研究生院和细胞工程所涉及的内容；(4)在课堂教学和研究小组会议中纳入主动学习和写作分析，以促进深度学习。