The impact of Hyaluronic Acid on growth factor signalling and angiogenesis

透明质酸对生长因子信号传导和血管生成的影响

• 批准号: DP240101674
• 负责人: A/Prof Kelly Smith
• 金额: $ 39.42万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101674
• 关键词: impact; Hyaluronic; Acid; growth; factor

Blood vessel development is controlled by growth factor signalling. Vessels are attracted by and migrate along growth factor gradients, and this is controlled by the extracellular matrix (ECM). From the zebrafish model, we have identified a novel gene that modulates the ECM, impacting growth factor signalling and vessel development. The project will explore by what mechanism this gene impacts signalling. It will comprehensively define where in the embryo it is required and investigate what cofactors it interacts with to perform its function. Using genetic zebrafish and mouse models as well as cell culture models we will investigate the fundamental biology of this gene.

血管发育受生长因子信号控制。血管被生长因子吸引并沿着生长因子梯度迁移，这是由细胞外基质（ECM）控制的。从斑马鱼模型中，我们发现了一种调节ECM的新基因，影响生长因子信号传导和血管发育。该项目将探索这种基因影响信号传递的机制。它将全面定义胚胎中需要它的地方，并研究它与什么辅因子相互作用以执行其功能。利用遗传斑马鱼和小鼠模型以及细胞培养模型，我们将研究该基因的基本生物学。