Dissertation Research:Identifying Genetic Mechanisms of Dental Variation in Anthropoid Primates

论文研究：识别类人灵长类动物牙齿变异的遗传机制

• 批准号: 9903435
• 负责人: Alan Walker
• 金额: $ 1.2万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9903435&HistoricalAwards=false
• 关键词: Dissertation; Research; Identifying; Genetic; Mechanisms

This project investigates the evolution of primate teeth using a novel integration of paleontology and genetics. Dental traits (characteristics) will be measured for 300 animals from a colony of 3,000 baboons housed at the Southwest Foundation for Biomedical Research in San Antonio, Texas. We will investigate dental traits known from the fossil record of baboons as well as new ones identified through the study of tooth development. Family trees are kept for the Southwest Foundation baboons, so that we know each individual's mother, father, siblings, etc. Inheritance patterns of the dental traits will be determined using the pedigree data and probability tests. This analysis will identify traits that are linked to others and those that have a strong genetic signal. Traits that appear to follow a clear genetic inheritance pattern will then be tested, again using probability theory, to determine if particular ones correlate with particular regions of the genome. This is possible, since genome maps have been made for 700 of the animals. Using this method, we may be able to pinpoint regions of the genome that contain genes involved in tooth development. This is the first project to attempt to identify genes acting on tooth development using information from teeth themselves. Results from this study will give us a better understanding of the genetic mechanisms underlying traits seen in the fossil record and may ultimately lead to the identification of genes that play a large role in tooth development in humans as well as non-human primates.

该项目使用古生物学和遗传学的新型整合来研究灵长类牙齿的演变。 将对来自德克萨斯州圣安东尼奥市西南生物医学研究基金会的3,000个狒狒的殖民地的300种动物进行牙齿特征（特征）。 我们将研究从狒狒的化石记录以及通过牙齿发育研究所确定的新的牙科特征。 西南基金会狒狒的家谱保存，以便我们知道每个人的母亲，父亲，兄弟姐妹等。牙科特征的继承模式将使用谱系数据和概率测试确定。 该分析将确定与他人以及具有强大遗传信号的特征。 然后，似乎遵循明确的遗传遗传模式的特征将再次使用概率理论测试，以确定特定的特征是否与基因组的特定区域相关。 这是可能的，因为已经为700只动物制作了基因组图。 使用这种方法，我们可能能够查明包含参与牙齿发育基因的基因组的区域。 这是第一个尝试使用牙齿本身的信息来识别对牙齿发育作用的基因的第一个项目。 这项研究的结果将使我们更好地了解化石记录中所见特征的遗传机制，并最终可能导致鉴定在人类以及非人类灵长类动物中发育中发挥重要作用的基因。