Smart biomaterials

该项目旨在设计光触发材料，通过使用紫外线不稳定的笼状配体来动态呈现和/或释放生物粘附基。我们假设这些紫外线触发的笼状生物粘附配体将在体外和体内对细胞-物质相互作用提供精确的控制。我们建议开发两种具有可触发黏附RGD配体的生物材料平台（表面，水凝胶），以研究细胞过程中时空黏附的影响。提出的研究将产生一种通用的生物材料策略，用于精确的生物功能时空控制。然后，这些创新的生物材料将用于在体外和体内提供细胞-生物材料相互作用的新见解。此外，对工程可触发水凝胶的关注为转化为许多生物技术和生物医学应用提供了途径。

This project aims to engineer phototriggerable materials to dynamically present and/or release bioadhesive motifs via the use of UV-labile caged ligands. We hypothesize that these UV-triggerable caged bioadhesive ligands will provide precise control over cell-material interactions in vitro and in vivo. We propose to develop two biomaterial platforms (surfaces, hydrogels) with triggerable adhesive RGD ligands in order to investigate the effects of spatiotemporal adhesion in cell processes.The proposed research will generate a general biomaterial strategy for precise spatiotemporal control of biological functionalities. These innovative biomaterials will then be used to provide new insights on cell-biomaterial interactions in vitro and in vivo. Furthermore, the focus on engineering triggerable hydrogels provides a pathway for translation into many biotechnological and biomedical applications.