Toxicology, Insect Specificity, and Chemistry of a Novel Peptidic Insecticide - TMOF

新型肽类杀虫剂的毒理学、昆虫特异性和化学 - TMOF

• 批准号: 9903837
• 负责人: Ronald Stinner
• 金额: $ 24.75万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-10-01 至 2002-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9903837&HistoricalAwards=false
• 关键词: Toxicology; Insect; Specificity; Chemistry; Novel

EEC-9903837Stinner/North Carolina State U.This project is supported under the initiative on "Research Centers - Small Firms Collaborative R&D." The study concerns joint research between the Center for Integrated Pest Management, an NSF IUCRC, and Insect Biotechnology, Inc., a small firm in Durham, NC. Insect Biotechnology, Inc. (IBI) is developing a new, biorational insecticide technology (Trypsin Modulating Oostatic Factor, TMOF) that is target specific, nontoxic to nontarget organisms, and biodegradable with a short half-life in the environment. In the present study, techniques will be developed to ascertain the presence of the TMOF mechanism in a given insect species, to perform bioassays for the TMOF compound(s) and isolate and characterize the active TMOF chemical species. Chemical compounds designed to mimic these new TMOFs will be synthesized and tested for activity. IBI will assign one postdoctoral trainee to work in the Center. Personnel of the Center and IBI will hold bimonthly meetings. IBI will prepare and assay TMOF peptide analogues. This technology represents a new pest control tool with wide applicability, coupled with environmental and health safety and is a key to management options under the new Food Quality Protection Act regulations being promulgated by EPA. This project offers IBI the opportunity to interact with key corporate members of the Center (and vice versa) to enhance the incorporation of IBI's technology into new management schemes and older mainstream products. The firm's peptide-based technology has a potential to be one of the next generation of biorational, safe insecticides.

EEC-9903837 Stinner/北卡罗来纳州州立大学。该项目在“研究中心-小公司合作研发”倡议下得到支持。“这项研究涉及综合害虫管理中心、NSF IUCRC和昆虫生物技术公司之间的联合研究，北卡罗来纳州达勒姆的一家小公司。 Insect Biotechnology，Inc. (IBI)正在开发一种新的、生物合理的杀虫剂技术（胰蛋白酶调节促排卵因子，TMOF），该技术具有目标特异性、对非目标生物无毒、可生物降解且在环境中半衰期短。 在本研究中，将开发技术，以确定在一个给定的昆虫物种的TMOF机制的存在下，进行生物测定的TMOF化合物（S）和分离和表征的活性TMOF化学物种。将合成旨在模拟这些新TMOFs的化合物并测试其活性。 IBI将派遣一名博士后在中心工作。 中心和IBI的工作人员将每两个月举行一次会议。 IBI将制备和分析TMOF肽类似物。这项技术代表了一种新的害虫控制工具，具有广泛的适用性，加上环境和健康安全，是美国环保局颁布的新食品质量保护法法规下的管理选择的关键。 该项目为IBI提供了与该中心的主要企业成员互动的机会（反之亦然），以加强IBI的技术融入新的管理方案和旧的主流产品。 该公司的肽基技术有可能成为下一代生物合理、安全的杀虫剂之一。