RUI: Role of EPH Molecules in Cochlear and Vestibular Neurite Outgrowth

RUI：EPH 分子在耳蜗和前庭神经突生长中的作用

• 批准号: 9904566
• 负责人: Lynne Bianchi
• 金额: $ 18万
• 依托单位: Oberlin College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-15 至 2003-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9904566&HistoricalAwards=false
• 关键词: RUI; Role; EPH; Molecules; Cochlear

During development, neurons (nerve cells) produce long extensions called neurites, which can make long-distance, highly specific connections to target cells in the brain. Many investigations have shown that particular molecules act as markers or regulators of this outgrowth. One of the classes of molecules is known as the 'Eph' family. This project uses molecular and anatomical techniques to show when and where the molecular receptor molecules in nerve cell membranes bind to the Eph molecules. A novel approach combines studies in vitro and in vivo, using bioassays and mutant mice to discover how the regulation of the binding may initiate, inhibit or modify the outgrowth and directional heading of neurites in the nerve from the developing mammalian ear. Results will be important to understanding the formation of a major sensory pathway, as well as for developmental processes in general. This RUI project also has a strong impact on education, by training undergraduates in research.

在发育过程中，神经元（神经细胞）产生长的延伸称为神经突，它可以与大脑中的靶细胞进行长距离，高度特异性的连接。 许多研究表明，特定的分子作为标记物或调节剂的这种产物。 其中一类分子被称为“Eph”家族。 该项目使用分子和解剖技术来显示神经细胞膜中的分子受体分子何时何地与Eph分子结合。 一种新的方法结合了体外和体内的研究，使用生物测定和突变小鼠来发现结合的调节如何启动，抑制或修改发育中的哺乳动物耳朵神经中神经突的生长和定向标题。 结果将是重要的理解形成的一个主要的感觉通路，以及一般的发育过程。 这个RUI项目也对教育产生了很大的影响，通过培训本科生进行研究。