Mechanistic and Synthetic Studies on Highly Reactive Metals

高活性金属的机理和合成研究

• 批准号: 9906570
• 负责人: Reuben Rieke
• 金额: $ 34.5万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9906570&HistoricalAwards=false
• 关键词: Mechanistic; Synthetic; Studies; Highly; Reactive

The objective of this project is the study and development of novel organometallic chemistry using highly reactive metals. Theoretical and mechanistic studies will be undertaken in addition to synthetic methods development. Of particular interest is the development of selective metallation reactions using a variety of highly reactive metals including Zn, Mn, Ni, and Cu. The types of selectivities that are being developed include substrate selectivity according to degree substitution at halogen, as well as functional group tolerance during metallation. Reactions in which oxygenated functional groups act analogously to halogens are also anticipated, providing additional flexibility in the design of organometal-based reaction schemes.With this Award, the Organic and Macromolecular Chemistry Program continues support for the research of Professor Reuben D. Reike of the University of Nebraska. Professor Reike leads an ongoing effort to discover new ways to incorporate metal atoms into the structure of otherwise purely organic molecules. These organometallic species hold an indispensible place in the arsenal of synthetic organic chemists because they can be used in a variety of reactions that quickly increase the size and complexity of the resulting molecule.

该项目的目标是研究和开发使用高活性金属的新型有机金属化学。 除了合成方法开发之外，还将进行理论和机理研究。 特别令人感兴趣的是使用各种高反应性金属（包括锌、锰、镍和铜）的选择性金属化反应的发展。 正在开发的选择性类型包括根据卤素取代度的底物选择性，以及金属化过程中的官能团耐受性。 含氧官能团的反应类似于卤素，这为有机金属反应方案的设计提供了额外的灵活性。通过该奖项，有机和高分子化学项目将继续支持内布拉斯加大学 Reuben D. Reike 教授的研究。 雷克教授一直致力于探索将金属原子纳入纯有机分子结构的新方法。 这些有机金属物质在合成有机化学家的武器库中占有不可或缺的地位，因为它们可用于各种反应，从而快速增加所得分子的尺寸和复杂性。