Mechanistic and Synthetic Studies on Highly Reactive Metals

本项目的目标是研究和开发使用高活性金属的新型有机金属化学。除了合成方法的开发外，还将进行理论和机理研究。特别令人感兴趣的是使用包括锌、锰、镍和铜在内的各种高活性金属的选择性金属化反应的发展。正在开发的选择性类型包括根据卤素取代程度的底物选择性，以及金属化过程中的官能团容差。含氧官能团类似于卤素的反应也被预期，为基于有机金属的反应方案的设计提供了额外的灵活性。有了这个奖，有机和高分子化学计划继续支持内布拉斯加大学的鲁本·D·雷克教授的研究。雷克教授正在领导一项正在进行的努力，以发现将金属原子结合到纯有机分子结构中的新方法。这些有机金属物种在合成有机化学家的武器库中占有不可或缺的地位，因为它们可以用于各种反应，这些反应迅速增加了生成的分子的大小和复杂性。

The objective of this project is the study and development of novel organometallic chemistry using highly reactive metals. Theoretical and mechanistic studies will be undertaken in addition to synthetic methods development. Of particular interest is the development of selective metallation reactions using a variety of highly reactive metals including Zn, Mn, Ni, and Cu. The types of selectivities that are being developed include substrate selectivity according to degree substitution at halogen, as well as functional group tolerance during metallation. Reactions in which oxygenated functional groups act analogously to halogens are also anticipated, providing additional flexibility in the design of organometal-based reaction schemes.With this Award, the Organic and Macromolecular Chemistry Program continues support for the research of Professor Reuben D. Reike of the University of Nebraska. Professor Reike leads an ongoing effort to discover new ways to incorporate metal atoms into the structure of otherwise purely organic molecules. These organometallic species hold an indispensible place in the arsenal of synthetic organic chemists because they can be used in a variety of reactions that quickly increase the size and complexity of the resulting molecule.