Proteins of Oxygen-Binding and Energy Metabolism in Muscles of Antarctic Fishes: Evolutionary Adjustments to Life at Cold Temperature

南极鱼类肌肉中的氧结合和能量代谢蛋白质:低温下生活的进化调整

基本信息

  • 批准号:
    9909055
  • 负责人:
  • 金额:
    $ 32.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-04-01 至 2003-03-31
  • 项目状态:
    已结题

项目摘要

The suborder Notothenoidei is the dominant fish group of the Southern Ocean surrounding Antarctica, both in terms of number of species and biomass. For about fourteen million years, these highly successful fish evolved under stable thermal conditions that result in body temperatures of about zero degrees centigrade throughout their life histories. Evolution this cold environment has led to unusual physiological and biochemical characteristics. In some cases, the characteristics contribute to overcoming constraints of cold temperature on biological processes. In other instances, mutations that probably would have been lethal in warmer, less oxygen-rich environments than the Southern Ocean have been retained in Antarctic fishes. This research project focuses on three major objectives that exploit these unusual conditions to identify mechanisms compatible with normal cellular function at cold temperature and to gain unique insights into the physiological roles of key intracellular proteins. The three lines of study proposed are the molecular basis for the failure of the myoglobin encoding gene to be expressed in certain Antarctic notothenioid fishes, the basis of the substrate specificity of the enzyme fatty acyl-CoA synthetase that is involved in the catabolism of fatty acids, and the functional roles played by different isoforms of creatine phosphokinase in locomotory muscle of Antarctic fish. Results from this study will not only provide insight into the evolutionary biology of the Antarctic notothenioid fishes, but will elucidate important general principles that are applicable to widely different taxa beyond the Antarctic.
Notothenoidei亚目是南极周围南大洋的主要鱼类群体,无论是在物种数量还是生物量方面。在大约1400万年的时间里,这些非常成功的鱼类在稳定的温度条件下进化,导致它们整个生命史的体温约为零摄氏度。这种寒冷的进化环境导致了异常的生理和生化特征。在某些情况下,这些特性有助于克服低温对生物过程的限制。在其他情况下,在比南大洋更温暖、氧气更少的环境中可能致命的突变被保留在南极鱼类中。该研究项目的重点是三个主要目标,利用这些不寻常的条件来确定在低温下与正常细胞功能相容的机制,并获得对关键细胞内蛋白质生理作用的独特见解。提出的三条研究路线是肌红蛋白编码基因在某些南极notothenioid鱼类中表达失败的分子基础,脂肪酰辅酶A合成酶的底物特异性的基础,该酶参与脂肪酸的催化,以及肌酸磷酸激酶的不同亚型在南极鱼类运动肌肉中发挥的功能作用。这项研究的结果不仅将提供深入了解南极notothenioid鱼类的进化生物学,但将阐明重要的一般原则,适用于广泛不同的类群超越南极。

项目成果

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Bruce Sidell其他文献

Bruce Sidell的其他文献

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{{ truncateString('Bruce Sidell', 18)}}的其他基金

Collaborative Research: Differential Expression of Oxygen-binding Proteins in Antarctic Fishes Affects Nitric Oxide-mediated Pathways of Angiogenesis and Mitochondrial Biogenesis.
合作研究:南极鱼类氧结合蛋白的差异表达影响一氧化氮介导的血管生成和线粒体生物发生途径。
  • 批准号:
    0437887
  • 财政年份:
    2005
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Continuing Grant
Cold Body Temperature as an Evolutionary Shaping force in the Physiology of Antarctic Fishes
寒冷的体温作为南极鱼类生理学的进化塑造力
  • 批准号:
    0125890
  • 财政年份:
    2002
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Continuing Grant
Evolution of an Oxygen-Binding Hemoprotein in a Unique Environment: Myoglobin in the Hemoglobinless Antarctic Icefishes
独特环境中氧结合血红素蛋白的进化:无血红蛋白南极冰鱼中的肌红蛋白
  • 批准号:
    9421657
  • 财政年份:
    1996
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Continuing Grant
Adaptations to Counter Diffusional Constraints in Muscle of Channichthyid Icefishes
鳅鱼肌肉对抗扩散限制的适应
  • 批准号:
    9220775
  • 财政年份:
    1993
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Continuing Grant
Metabolic and Ultrastructural Adaptations to Chronically Cold Body Temperature in Antarctic Fishes
南极鱼类对长期寒冷体温的代谢和超微结构适应
  • 批准号:
    8819469
  • 财政年份:
    1990
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Continuing Grant
Energetic and Respiratory Role of Lipids in Thermally Acclimated Fish
热适应鱼中脂质的能量和呼吸作用
  • 批准号:
    8811209
  • 财政年份:
    1988
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Continuing Grant
Role of Lipid Fuels in Muscular Activity of Thermally- Acclimated Fish
脂质燃料在热适应鱼肌肉活动中的作用
  • 批准号:
    8518442
  • 财政年份:
    1986
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Standard Grant
Characterization of Energy Metabolism in Antarctic Fish
南极鱼类能量代谢的特征
  • 批准号:
    8516137
  • 财政年份:
    1986
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Continuing Grant
Structure/Function Adaptations to Environmental Temperature In Fish Skeletal Muscle
鱼类骨骼肌对环境温度的结构/功能适应
  • 批准号:
    8104112
  • 财政年份:
    1981
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Continuing Grant
Physiological Adaptation of Teleost Fish to Cold Temperatures
硬骨鱼类对寒冷温度的生理适应
  • 批准号:
    7716838
  • 财政年份:
    1977
  • 资助金额:
    $ 32.1万
  • 项目类别:
    Standard Grant

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金属卟啉配合物的氧结合行为研究及其在氧吸附和解吸装置中的应用
  • 批准号:
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雄珠蛋白的功能分析,一种与男性不育相关的新型氧结合蛋白。
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EAPSI: Modifying Proteins to Investigate Key Intermediates in Oxygen Binding Enzymes
EAPSI:修饰蛋白质以研究氧结合酶的关键中间体
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