Evolution of an Oxygen-Binding Hemoprotein in a Unique Environment: Myoglobin in the Hemoglobinless Antarctic Icefishes

独特环境中氧结合血红素蛋白的进化:无血红蛋白南极冰鱼中的肌红蛋白

基本信息

  • 批准号:
    9421657
  • 负责人:
  • 金额:
    $ 58.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    1996
  • 资助国家:
    美国
  • 起止时间:
    1996-02-01 至 2001-01-31
  • 项目状态:
    已结题

项目摘要

9421657 Sidell For approximately the last 40 million years, a unique fish fauna has been evolving in the frigid seas surrounding Antarctica. Physiological function of these water-breathing animals has demanded many adaptations to ensure proper metabolism and regulation of biochemical processes at cell temperatures of about OoC. Among the polar fishes, one family is particularly unusual, the Channichthyid icefishes. Species in this family lack hemoglobin in their circulating blood and, at least the majority, do not possess the intracellular respiratory protein, myoglobin, that is normally responsible for enhancing movement of oxygen through aerobic muscle tissues. The PI's have recently found two species of icefish, Pseudochaenichthys georgianus and Chionodraco rastrospinosus, however, that express myoglobin, but only in one tissue - heart ventricle. The metabolism of all icefish species is highly aerobic and is based largely on the combustion of fatty fuels as energy sources. The field work will consist of a combination of trawling from R/V Polar Duke to capture icefish species and laboratory work at Palmer Station using tissues from these animals. At Palmer Station they will conduct experiments and prepare purified, fixed and or frozen material for shipment back to our CONUS laboratory for further analyses. Our overall goals are: 1) to test whether to determine myoglobin protein remains physiologically significant at the cold body temperatures of Antarctic fishes, 2) to reconstruct the evolution of the myoglobin gene within the icefish family and, 3) to identify the mechanisms controlling expression of myoglobin within icefish and related species.
在过去的大约4000万年里,在南极洲周围寒冷的海洋中,一种独特的鱼类群一直在进化。这些水呼吸动物的生理功能需要许多适应,以确保适当的代谢和调节细胞温度下的生化过程。在极地鱼类中,有一个科特别不寻常,那就是冰鱼科冰鱼。这个科的物种在它们的循环血液中缺乏血红蛋白,并且,至少大多数,不具有细胞内呼吸蛋白,肌红蛋白,这种蛋白通常负责通过有氧肌肉组织加强氧气的运动。PI最近发现了两种冰鱼,乔治亚假chchaenichthys和Chionodraco rasstrospinosus,它们表达肌红蛋白,但只在一个组织-心脏心室中。所有种类的冰鱼的新陈代谢都是高度有氧的,主要是基于燃烧脂肪燃料作为能量来源。实地工作将包括从“极地公爵号”上进行拖网捕鱼以捕获冰鱼,以及在帕尔默站使用这些动物的组织进行实验室工作。在帕尔默站,他们将进行实验并准备纯化,固定和/或冷冻的材料,以便运回我们的CONUS实验室进行进一步分析。我们的总体目标是:1)测试在南极鱼类的低温下肌红蛋白是否仍然具有生理意义;2)重建冰鱼家族中肌红蛋白基因的进化;3)确定冰鱼和相关物种中肌红蛋白表达的控制机制。

项目成果

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Bruce Sidell其他文献

Bruce Sidell的其他文献

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{{ truncateString('Bruce Sidell', 18)}}的其他基金

Collaborative Research: Differential Expression of Oxygen-binding Proteins in Antarctic Fishes Affects Nitric Oxide-mediated Pathways of Angiogenesis and Mitochondrial Biogenesis.
合作研究:南极鱼类氧结合蛋白的差异表达影响一氧化氮介导的血管生成和线粒体生物发生途径。
  • 批准号:
    0437887
  • 财政年份:
    2005
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Continuing Grant
Cold Body Temperature as an Evolutionary Shaping force in the Physiology of Antarctic Fishes
寒冷的体温作为南极鱼类生理学的进化塑造力
  • 批准号:
    0125890
  • 财政年份:
    2002
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Continuing Grant
Proteins of Oxygen-Binding and Energy Metabolism in Muscles of Antarctic Fishes: Evolutionary Adjustments to Life at Cold Temperature
南极鱼类肌肉中的氧结合和能量代谢蛋白质:低温下生活的进化调整
  • 批准号:
    9909055
  • 财政年份:
    2000
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Continuing Grant
Adaptations to Counter Diffusional Constraints in Muscle of Channichthyid Icefishes
鳅鱼肌肉对抗扩散限制的适应
  • 批准号:
    9220775
  • 财政年份:
    1993
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Continuing Grant
Metabolic and Ultrastructural Adaptations to Chronically Cold Body Temperature in Antarctic Fishes
南极鱼类对长期寒冷体温的代谢和超微结构适应
  • 批准号:
    8819469
  • 财政年份:
    1990
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Continuing Grant
Energetic and Respiratory Role of Lipids in Thermally Acclimated Fish
热适应鱼中脂质的能量和呼吸作用
  • 批准号:
    8811209
  • 财政年份:
    1988
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Continuing Grant
Role of Lipid Fuels in Muscular Activity of Thermally- Acclimated Fish
脂质燃料在热适应鱼肌肉活动中的作用
  • 批准号:
    8518442
  • 财政年份:
    1986
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Standard Grant
Characterization of Energy Metabolism in Antarctic Fish
南极鱼类能量代谢的特征
  • 批准号:
    8516137
  • 财政年份:
    1986
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Continuing Grant
Structure/Function Adaptations to Environmental Temperature In Fish Skeletal Muscle
鱼类骨骼肌对环境温度的结构/功能适应
  • 批准号:
    8104112
  • 财政年份:
    1981
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Continuing Grant
Physiological Adaptation of Teleost Fish to Cold Temperatures
硬骨鱼类对寒冷温度的生理适应
  • 批准号:
    7716838
  • 财政年份:
    1977
  • 资助金额:
    $ 58.7万
  • 项目类别:
    Standard Grant

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金属卟啉配合物的氧结合行为研究及其在氧吸附和解吸装置中的应用
  • 批准号:
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