Polymer Dynamics and Biophysics with Single Molecules

单分子聚合物动力学和生物物理学

• 批准号: 9970017
• 负责人: Steven Chu
• 金额: $ 169.94万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9970017&HistoricalAwards=false
• 关键词: Polymer; Dynamics; Biophysics; Single; Molecules

9970017ChuThis award supports a series of projects in the related areas of polymer physics and biophysics, all of which capitalize on the utilization of techniques involving controlling molecular motion with laser tweezers and optical imaging of biological polymers. Inherent in the work is a focus on the extraction of details of the behavior of polymers from the analysis of single molecules. All measurements will be accompanied by the development of new experimental tools which extend the present capabilities of instruments. Projects will include, among others, the study of polymers in shear and elongational flows, Brownian motion of polymers in solution, and combining fluorescence resonance energy transfer with observation with an atomic force microscope. Funding for this award is provided by the Atomic, Molecular, Optical, and Plasma Physics program in the Physics Division, the Polymers program in the Division of Materials Research, and the Office of Multidisciplinary Activities in the Mathematical and Physical Sciences Directorate and the Molecular Biophysics program in the Division of Molecular and Cellular Biosciences in the Directorate for Biological Sciences.

9970017 Chu该奖项支持聚合物物理和生物物理相关领域的一系列项目，所有这些项目都利用了涉及用激光镊子控制分子运动和生物聚合物光学成像的技术。 这项工作的本质是专注于从单分子分析中提取聚合物行为的细节。 所有测量都将伴随着新的实验工具的开发，这些工具将扩展现有仪器的能力。 项目将包括，除其他外，在剪切和拉伸流动，聚合物在溶液中的布朗运动的聚合物的研究，并结合荧光共振能量转移与原子力显微镜观察。 该奖项的资金由物理系的原子，分子，光学和等离子体物理计划，材料研究部的聚合物计划，数学和物理科学理事会的多学科活动办公室以及生物科学理事会分子和细胞生物科学部的分子生物物理计划提供。