Eicosanoids in Tick Salivary Gland Physiology

蜱唾液腺生理学中的类花生酸

• 批准号: 9974299
• 负责人: John Sauer
• 金额: $ 23.1万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-10-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9974299&HistoricalAwards=false
• 关键词: Eicosanoids; Tick; Salivary; Gland; Physiology

Prostaglandins ( type of eicosanoid molecule) are extremely important in mammals and other vertebrates. Cyclooxygenase, which converts arachidonic acid to prostaglandins, is the target for most of the widely used anti-inflammatory drugs such as aspirin, ibuprofen, etc. A prostaglandin E2 receptor has been identified in the salivary glands of the lone star tick, demonstrating for the first time, a prostaglandin receptor in an invertebrate. Prostaglandin E2, through its receptor, stimulates secretion of saliva protein clearly demonstrating a function for an eicosanoid in tick salivary gland physiology.The proposal research by Dr. Sauer will identify all eicosanoids in tick salivary glands. Research will also analyze syntheis of prostaglandin E2 and whether synthesis is sensitive to some of the same anti-inflamatory drugs shown to effective in inhibiting synthesis in mammals and other vertebrates. The research will also exaimen the mode of action of prostaglandin E2 in eliciting secretion of saliva protein.As more is learned about the tick's physiology it may be possible to develop agents (e.g. drugs which target protaglandin systensis enzymes) or other treatments that will neutralize the harm caused by tick feeding.

前列腺素（类花生酸分子的类型）在哺乳动物和其他脊椎动物中极其重要。 环氧合酶，将花生四烯酸转化为洋地黄素，是大多数广泛使用的抗炎药物如阿司匹林、布洛芬等的靶点。在孤星星蜱的唾液腺中已鉴定出前列腺素E2受体，首次证明了无脊椎动物中的前列腺素受体。 前列腺素E2通过其受体刺激唾液蛋白的分泌，清楚地证明了类花生酸在蜱唾液腺生理学中的功能。Sauer博士的提案研究将鉴定蜱唾液腺中的所有类花生酸。 研究还将分析前列腺素E2的合成，以及合成是否对某些在哺乳动物和其他脊椎动物中有效抑制合成的抗炎药物敏感。 这项研究还将检验前列腺素E2在引发唾液蛋白分泌中的作用模式。随着对蜱虫生理学的了解越来越多，可能会开发出药物（例如针对前列腺素系统酶的药物）或其他治疗方法，以中和蜱虫进食造成的伤害。