Coordination and Bioinorganic Chemistry with Sulfur Ligands

硫配体的配位和生物无机化学

• 批准号: 9974628
• 负责人: Charles Riordan
• 金额: $ 30万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9974628&HistoricalAwards=false
• 关键词: Coordination; Bioinorganic; Chemistry; Sulfur; Ligands

Dr. Charles G. Riordan, Chemistry Department, University of Delaware is supported by the Inorganic, Bioinorganic, and Organometallic Program to develop the coordination and bioinorganic chemistry of the poly(thioether)borates. Significant features of these new ligands include an overall anionic charge, highly polarizable thioether donors, and a synthetic versatility that permits inocrporation of a range of sulfur substituents. The ligands will be used as supporting ligands to investigate the bioinorganic chemistry of zinc, to direct the reactivity of tetrahedral cobalt and nickel complexes, and to form three coordinate metal thiolate complexes. The development of these new species is important to accurately model the active sites in metal containing proteins and enzymes. In addition, these studies will have broad implications to the understanding of a range of catalytic industrial and biological processes.

Charles G.博士Riordan，化学系，特拉华州的大学是由无机，生物无机和有机物计划的支持，以开发聚（硫醚）硼酸盐的配位和生物无机化学。这些新配体的显著特征包括总阴离子电荷、高度可极化的硫醚供体以及允许一系列硫取代基的合成通用性。这些配体将被用作支持配体，以研究锌的生物无机化学，指导四面体钴和镍配合物的反应性，并形成三配位金属硫醇盐配合物。这些新物种的开发对于准确模拟含金属蛋白质和酶中的活性位点非常重要。此外，这些研究将对理解一系列催化工业和生物过程产生广泛的影响。