MRI: Acquisition of a High Resolution Mass Spectrometer for Small Molecule Analysis

来自特拉华大学的Charles Riordan教授及其同事Donald Watson和Joel Rosenthal将获得一台高分辨率质谱仪（HRMS），该奖项来自主要研究仪器（MRI）项目，该项目也由化学催化项目共同资助。该建议旨在加强各级的研究培训和教育，特别是在(a)反应发现和表面图案等领域；(b)细菌激活先天免疫系统；(c)微生物能量代谢；(d)生物质衍生化学中间体的催化升级；(e)镍氧化学；(f)太阳能燃料和可再生能源；(g)低价铬配合物的制备、反应性和催化活性；(h)过渡金属催化反应的发展；(1)镍和铜催化缩醛和羧酸盐的反应。高分辨率质谱仪通过从中产生离子来分析样品，这些离子被注入到光谱仪中，在那里它们的质量/电荷比被高精度地测量出来。所获得的质量信息提供了样品化学成分的定性和定量信息。该仪器使用多种工具注入样品并使其电离，这将允许分析从液体到固体的广泛小分子。该奖项提供的仪器将为几个部门的教师和学生提供使用最先进仪器进行研究项目的机会。它还将用于几个实验课程，以训练本科生使用这种广泛使用的分析工具。特拉华大学的质谱仪设施将与该地区的一些机构合作并共享仪器，包括特拉华州立大学、林肯大学、华盛顿大学、布林莫尔学院和德雷塞尔大学。

With this award from the Major Research Instrumentation (MRI) Program that is also co-funded by the Chemical Catalysis Program, Professor Charles Riordan from the University of Delaware and colleagues Donald Watson and Joel Rosenthal will acquire a high-resolution mass spectrometer (HRMS). The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) reaction discovery and surface patterning; (b) bacterial activation of the innate immune system; (c) microbial energy metabolism; (d) catalytic upgrading of biomass-derived chemical intermediates;(e) nickel-oxygen chemistry; (f) solar fuels and renewable energy; (g) preparation, reactivity, and catalytic activity of low-valent chromium complexes; (h) development of transition metal catalyzed reactions; and (i) nickel- and copper-catalyzed reactions of acetals and carboxylates.A high resolution mass spectrometer analyzes samples by creating ions from it which are injected into the spectrometer where their mass/charge ratios are measured to high accuracy. The mass information that is obtained provides qualitative and quantitative information on the chemical composition of the sample. This instrument uses a variety of tools to inject the sample and ionize it, which will allow a broad range of small molecules to be analyzed from liquids to solids. The instrumentation provided by this award will provide faculty and students in several departments the opportunity to pursue research projects using state-of-the-art instrumentation. It will also be used in several laboratory courses to train undergraduate students in the use of this widely employed analytical tool. The mass spectrometer facility at the university of Delaware will partner and share the instrument with a number of institutions in the region including, Delaware State University, Lincoln University, Washington University, Bryn Mawr College and Drexel University.