Adaptive Mutations: A Consequence of Prokaryotic Differentiation
适应性突变:原核分化的结果
基本信息
- 批准号:9975140
- 负责人:
- 金额:$ 33.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-03-01 至 2004-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In 1988, John Cairns and his collaborators discovered so-called "adaptive mutations" These observations, later enhanced by a series of investigators, suggested that some mutants arose in response to specific environmental challenges or situations. The nature of the mechanism that generates these "adaptive mutants" has been hotly debated. It now appears that these mutations are the result of a sub-population of cells that differentiate into a hypermutable state. The genetic control for this differentiation has not yet been elucidated. Preliminary investigations with the bacterial Bacillus subtilis model system indicate that in this organism the genetic mechanism(s) that regulate the development of the hypermutable state overlap with the mechanisms that regulate the processes of sporulation and competence (uptake of extracellular DNA). This project will utilize the knowledge of the genetic control of the processes of sporulation and competence development to delineate the molecular mechanisms responsible for the generation of "adaptive mutations." Using the information that is currently available, a working hypothesis for the generation of "adaptive" mutations would be that under stress, a small subset of cells differentiate into a hypermutable state, and these cells lack a functional DNA mismatch repair system. The research in this project is aimed at testing this hypothesis by utilizing the genetic and molecular biological techniques that have been developed for analyzing differentiation in the Gram-positive, spore forming bacterium Bacillus subtilis. Delineating this system is critical to our understanding of the role played by stress-induced genetic diversity mechanisms in species
1988年,约翰·凯恩斯(John Cairns)和他的合作者发现了所谓的“适应性突变”。这些观察结果后来被一系列研究者进一步证实,表明一些突变是对特定环境挑战或情况的反应。产生这些“适应性突变体”的机制的本质一直备受争议。现在看来,这些突变是细胞亚群分化成超可变状态的结果。这种分化的遗传控制尚未阐明。对枯草芽孢杆菌模型系统的初步研究表明,在这种生物中,调节超变状态发展的遗传机制与调节产孢过程和能力(细胞外DNA的摄取)的机制重叠。该项目将利用孢子形成和能力发展过程的遗传控制知识来描述负责产生“适应性突变”的分子机制。利用目前可获得的信息,产生“适应性”突变的一个有效假设是,在压力下,一小部分细胞分化成超可变状态,这些细胞缺乏功能性DNA错配修复系统。该项目的研究旨在通过利用遗传和分子生物学技术来验证这一假设,这些技术已被用于分析革兰氏阳性芽孢杆菌的分化。描述这一系统对我们理解应激诱导的物种遗传多样性机制所起的作用至关重要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ronald Yasbin其他文献
Ronald Yasbin的其他文献
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{{ truncateString('Ronald Yasbin', 18)}}的其他基金
Wind River Conference on Procaryotic Biology-Student Support to be held in summers of 2010, 2011, and 2012 at the Lodge in Estes Park Colorado
风河原核生物学会议 - 学生支持将于 2010 年、2011 年和 2012 年夏季在科罗拉多州埃斯蒂斯公园的旅馆举行
- 批准号:
1004405 - 财政年份:2010
- 资助金额:
$ 33.18万 - 项目类别:
Standard Grant
Wind River Conference on Procaryotic Biology, 51st-53rd annual meeting at Aspen Lodge in Estes Park, CO on June 6 - 10, 2007.
风河原核生物学会议,第 51-53 届年会,于 2007 年 6 月 6 日至 10 日在科罗拉多州埃斯蒂斯公园的 Aspen Lodge 举行。
- 批准号:
0651117 - 财政年份:2007
- 资助金额:
$ 33.18万 - 项目类别:
Standard Grant
Wind River Conferences on Procaryotic Biology
风河原核生物学会议
- 批准号:
0423995 - 财政年份:2004
- 资助金额:
$ 33.18万 - 项目类别:
Continuing Grant
Wind River Conferences on Procaryotic Biology
风河原核生物学会议
- 批准号:
0337922 - 财政年份:2003
- 资助金额:
$ 33.18万 - 项目类别:
Continuing Grant
Adaptive Mutations: A Consequence of Prokaryotic Differentiation
适应性突变:原核分化的结果
- 批准号:
0317076 - 财政年份:2003
- 资助金额:
$ 33.18万 - 项目类别:
Continuing Grant
Wind River Conference on Procaryotic Biology, to be held June 2001, 2002 and 2003
风河原核生物学会议,将于 2001 年、2002 年和 2003 年 6 月举行
- 批准号:
0102586 - 财政年份:2001
- 资助金额:
$ 33.18万 - 项目类别:
Standard Grant
Wind River Conference on Prokaryotic Biology, June 1998, 1999, and 2000 in Estes Park, CO
风河原核生物学会议,1998 年 6 月、1999 年和 2000 年在科罗拉多州埃斯蒂斯公园举行
- 批准号:
9802422 - 财政年份:1998
- 资助金额:
$ 33.18万 - 项目类别:
Standard Grant
Wind River Conference on Prokaryotic Biology, Allenspark, CO June 4-8, 1997
风河原核生物学会议,Allenspark,CO 1997 年 6 月 4-8 日
- 批准号:
9722500 - 财政年份:1997
- 资助金额:
$ 33.18万 - 项目类别:
Standard Grant
40th Wind River Conference on Procaryotic Biology, June 5-9, 1996 in Estes Park, Colorado
第 40 届风河原核生物学会议,1996 年 6 月 5-9 日在科罗拉多州埃斯蒂斯公园举行
- 批准号:
9600493 - 财政年份:1996
- 资助金额:
$ 33.18万 - 项目类别:
Standard Grant
39th Annual Meeting: Wind River Conference on Genetic Exchange, June 7-11, 1995, Estes Park, CO
第 39 届年会:风河基因交换会议,1995 年 6 月 7-11 日,科罗拉多州埃斯蒂斯帕克
- 批准号:
9501897 - 财政年份:1995
- 资助金额:
$ 33.18万 - 项目类别:
Standard Grant
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