Synthesis of phosphatidylinositol and inositol polyphosphate derivatives to probe key signalling proteins associated with cell growth and cancer

合成磷脂酰肌醇和肌醇多磷酸衍生物以探测与细胞生长和癌症相关的关键信号蛋白

• 批准号: DP1094497
• 负责人: Prof Andrew Holmes
• 金额: $ 37.62万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094497
• 关键词: Synthesis; phosphatidylinositol; inositol; polyphosphate; derivatives

Health care of an ageing population is a national priority of the community. In order to understand the factors that control cell growth and death in cancer cells signalling proteins can be identified and studied and compared with model systems from quiescent cells. Using phospholipids and inositol polyphosphates attached to 'fishing lines' we can search for, identify and study the function of many of the downstream signalling proteins in activated cancer cells. This will provide the basic information for discovery processes to target specific molecules that inhibit and control the function of the signalling proteins implicated in the growth of cancer cells.

老龄化人口的保健是社会的一项国家优先事项。为了了解癌细胞中控制细胞生长和死亡的因素，可以鉴定和研究信号蛋白，并将其与静止细胞的模型系统进行比较。利用附着在“钓鱼线”上的磷脂和肌醇多聚磷酸盐，我们可以搜索、鉴定和研究激活的癌细胞中许多下游信号蛋白的功能。这将为发现特定分子提供基本信息，这些分子可以抑制和控制与癌细胞生长有关的信号蛋白的功能。