Identifying mitogenic signalling proteins with phosphatidyl inositol lipids

用磷脂酰肌醇脂质鉴定促有丝分裂信号蛋白

• 批准号: DP0770668
• 负责人: Prof Andrew Holmes
• 金额: $ 43.75万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0770668
• 关键词: Identifying; mitogenic; signalling; proteins; phosphatidyl

Health care of an ageing population is a national priority of the community. In order to understand the factors that control cell growth and death in cancer cells signalling proteins can be identified and studied and compared with model systems from quiescent cells. Using phospholipids attached to 'fishing lines' we can search for, identify and study the function of all the downstream signalling proteins in activated cancer cells. This will provide the basic information for drug discovery processes to target specific molecules that inhibit and control the function of the signalling proteins implicated in the growth of cancer cells.

人口老龄化的保健是社区的国家优先事项。为了了解控制癌细胞生长和死亡的因素，可以识别和研究信号蛋白，并将其与静止细胞的模型系统进行比较。利用附着在“钓鱼线”上的磷脂，我们可以搜索、识别和研究激活癌细胞中所有下游信号蛋白的功能。这将为靶向抑制和控制与癌细胞生长有关的信号蛋白功能的特定分子的药物发现过程提供基础信息。