Mesoscopic 2D- and 3D-scaffolds made of spider silk proteins providing bacteriostatic surfaces and anti-bacterial properties (A08)

由蜘蛛丝蛋白制成的介观 2D 和 3D 支架，提供抑菌表面和抗菌特性 (A08)

• 批准号: 137809166
• 金额: --
• 依托单位: Lehrstuhl für Biomaterialien
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/137809166?language=en
• 关键词: Mesoscopic; 2D; 3D; scaffolds; made

In this project influences of molecular and varying processing parameters on distinct properties of recombinant spider silk materials have been investigated. The results reveal insights into molecular details of silk assembly. Based on the new findings it has been able to assemble biotech spider silk-like fibers with nature-like mechanical properties. Further, it has been possible to coat implants and catheters to improve their biocompatibility and to reduce unwanted side-effects upon implantation. Finally, self-supporting spider silk films were compounded with nanoclay to yield gas and water vapor barriers.

在这个项目中，分子和不同的工艺参数对重组蜘蛛丝材料的不同特性的影响进行了研究。这些结果揭示了丝组装的分子细节。基于新的发现，它已经能够组装具有天然机械性能的生物技术蜘蛛丝状纤维。此外，已经可以涂覆植入物和导管以改善它们的生物相容性并减少植入时的不希望的副作用。最后，将自支撑蜘蛛丝膜与纳米粘土复合以产生气体和水蒸气屏障。