Mesoscopic 2D- and 3D-scaffolds made of spider silk proteins providing bacteriostatic surfaces and anti-bacterial properties (A08)

在本项目中，研究了分子和不同的加工参数对重组蜘蛛丝材料不同性能的影响。研究结果揭示了丝绸组装的分子细节。基于这些新发现，该公司已经能够组装具有自然机械性能的生物技术蜘蛛丝状纤维。此外，还可以包覆植入物和导管，以改善其生物相容性并减少植入时不必要的副作用。最后，将自支撑蜘蛛丝薄膜与纳米粘土复合，形成气体和水蒸气屏障。

In this project influences of molecular and varying processing parameters on distinct properties of recombinant spider silk materials have been investigated. The results reveal insights into molecular details of silk assembly. Based on the new findings it has been able to assemble biotech spider silk-like fibers with nature-like mechanical properties. Further, it has been possible to coat implants and catheters to improve their biocompatibility and to reduce unwanted side-effects upon implantation. Finally, self-supporting spider silk films were compounded with nanoclay to yield gas and water vapor barriers.