Breaching membrane barriers

突破膜屏障

• 批准号: FT150100398
• 负责人: Dr Sonia Henriques
• 金额: $ 46.64万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-06-30 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT150100398
• 关键词: Breaching; membrane; barriers

This project will endeavour to develop novel molecular transporters to deliver macromolecules inside cells or microorganisms. Cell membranes are barriers to macromolecules. The ability to cross these barriers and deliver biological macromolecules into cells represents a major achievement with endless opportunities to modulate pathways and to introduce biomarkers, therapeutics and research tools. The project’s novel platform technology would be based on stable cyclic peptides to deliver genes, proteins, probes or biomarkers into distinct cell types that can monitor or modulate specific pathways and be translated into new knowledge and specific industrial applications.

本项目将致力于开发新型分子转运蛋白，将大分子物质运送到细胞或微生物内部。细胞膜是大分子的屏障。跨越这些障碍并将生物大分子递送到细胞中的能力代表了一项重大成就，具有无限的机会来调节途径并引入生物标志物，治疗剂和研究工具。该项目的新型平台技术将基于稳定的环肽，将基因、蛋白质、探针或生物标志物递送到不同的细胞类型中，这些细胞类型可以监测或调节特定的途径，并转化为新的知识和特定的工业应用。