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Spontaneous mutation affecting quantitative traits in Arabidopsis thaliana

影响拟南芥数量性状的自发突变

基本信息

批准号：
9981891
负责人：
Ruth Shaw
金额：
$ 40.4万
依托单位：
University of Minnesota-Twin Cities
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2000
资助国家：
美国
起止时间：
2000-02-01 至 2005-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9981891&HistoricalAwards=false
关键词：
Spontaneous mutation affecting quantitative traits

项目摘要

9981891ShawThis research will characterize spontaneous mutations affecting traits of Arabidopsis thaliana, an annual plant of the mustard family. The primary goals are to determine the mutation rate, to describe the distribution of mutational effects, and to assess genetic modes of action for spontaneous mutations. These studies will employ 117 mutation-accumulation lines that all derive from a single highly inbred progenitor, which serves as the genetic baseline. The lines have been advanced for 25 generations. Large-scale assays will be conducted using plants representing each line at several generations of line advancement. Measures of plant size, developmental timing, and reproduction will be obtained for each individual. The design of some assays varies environmental conditions so that environmental sensitivity of effects of mutation can be evaluated. Formal genetic crosses between lines will also be conducted to determine the degree of genetic dominance of mutations. Newly developed statistical approaches to inferring mutational properties will be applied to these data. Spontaneous mutation is widely recognized as a genetic process fundamentally important in evolution, yet quantitative information about spontaneous mutation is extremely limited. Results of this research will inform predictions about, for example, evolution of ecological specialization, evolution of mating systems, and rates of extinction.

9981891Shaw 这项研究将表征影响芥菜科一年生植物拟南芥性状的自发突变。主要目标是确定突变率，描述突变效应的分布，并评估自发突变的遗传作用模式。这些研究将采用 117 个突变积累系，这些系全部源自一个高度近交的祖先，作为遗传基线。该系列已发展了 25 代。将使用代表几代品系进步的每个品系的植物进行大规模测定。将对每个个体的植物大小、发育时间和繁殖进行测量。一些测定的设计会改变环境条件，以便可以评估突变影响的环境敏感性。还将进行品系之间的正式遗传杂交，以确定突变的遗传优势程度。新开发的推断突变特性的统计方法将应用于这些数据。自发突变被广泛认为是在进化中至关重要的遗传过程，但有关自发突变的定量信息却极其有限。这项研究的结果将为生态专业化的进化、交配系统的进化和灭绝率等方面的预测提供信息。