Novel Redox Self-Assembling Systems

有了这个更新奖，有机和高分子化学计划继续支持博士的工作。迈阿密大学的凯弗。 Kaifer博士和他的团队对电子转移反应和主客体分子识别的相互作用进行了基础研究。 将主体分子插入客体中可以改变复合物的电化学电势;相反，形成主体-客体复合物可以改变添加或移除电子的容易程度。 研究的系统类似于氧化还原蛋白质，拟议的工作可能会提供生物电子转移反应的见解。 Kaifer博士成功地吸引了少数民族学生加入他的团队。未来一段时间的研究将集中在具有不对称氧化还原中心的新型树枝状聚合物的合成和表征，以及自组装超分子结构的空穴和构建块，包括具有大中心空穴的六聚空穴和。 空穴配体是由间苯二酚和醛缩合得到的碗状大环化合物。 将使用表征技术的组合，包括伏安法、电喷雾质谱法、动态激光散射和尺寸排阻色谱法。

With this renewal award, the Organic and Macromolecular Chemistry Program is continuing support for the work of Dr. Angel E. Kaifer at the University of Miami. Dr. Kaifer and his group carry out fundamental investigations on the interplay of electron transfer reactions and host-guest molecular recognition. Inserting a host molecule into a guest can change the electrochemical potential of the complex; conversely, forming a host-guest complex can change the ease with which electrons can be added or removed. The systems studied resemble redox proteins, and the proposed work may provide insights into biological electron transfer reactions. Dr. Kaifer has been very successful in attracting minority students to work in his group.Research during the coming period will focus on the synthesis and characterization of novel dendrimers with unsymmetrically positioned redox centers, and of cavitand building blocks for self-assembling supramolecular structures, including hexameric cavitands with large central cavities. Cavitands are bowl-shaped macrocycles obtained from the condensation of resorcinols and aldehydes. A combination of characterization techniques will be used including voltammetry, electrospray mass spectroscopy, dynamic laser scattering, and size-exclusion chromatography.