Purchase of a Gradient-Equipped Magic-Angle-Spinning Probe and Gradient Amplifier for Solid-State Nuclear Magnetic Resonance

化学研究仪器和设施(CRIF)计划的这一奖项将使加州大学河滨分校的化学系能够购买用于固态核磁共振(核磁共振)的梯度配备的魔角旋转探头和梯度放大器。该设备将主要由初级教员Leonard J.Mueller使用，他的研究重点是：(1)开发多维固态核磁共振实验，用于高度标记C-13和N-15的生物样品的结构确定；以及(2)通过固态核磁共振对核酸中氢键的结构研究。这种最先进的合成技术和固态核磁共振的结合将扩大结构生物学的能力，并首次允许直接表征和系统研究核酸中的氢键几何结构。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will enable the Department of Chemistry at the University of California in Riverside to purchase a gradient-equipped magic-angle-spinning probe and gradient amplifier for solid-state nuclear magnetic resonance (NMR). This equipment will be used primarily by junior faculty member Leonard J. Mueller, whose research focuses on (1) the development of multidimensional solid-state NMR experiments for the structural determination of highly C-13 and N-15 labeled biological samples; and (2) structural studies of hydrogen bonding in nucleic acids via solid-state NMR. This combination of state-of-the-art synthetic techniques and solid-state NMR will expand the capabilities of structural biology and for the first time allow a direct characterization and systematic study of hydrogen bond geometries in nucleic acids.