Acquisition of High Field Nuclear Magnetic Resonance Instrumentation

购置高场核磁共振仪器

• 批准号: 9601831
• 负责人: Dallas Rabenstein
• 金额: $ 16万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9601831&HistoricalAwards=false
• 关键词: Acquisition; Field; Nuclear; Magnetic; Resonance

This award from the Academic Research Infrastructure (ARI) Program will assist the Department of Chemistry at the University of California Riverside upgrade the existing 500 MHz NMR. This equipment will enhance research in a number of areas including the following: (1) human erythrocytes, disulfide bonds in peptides and the interaction of peptides with heparin (2) structural studies of vitamin D in vitamin D-protein complexes (3) determination of non-standard nucleic acid structures (4) investigation of the roles played by low-barrier hydrogen bonds in enzyme catalysis, and (5) structure-function relationships for macromolecular structures of biological significance. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.

该学术研究基础设施 (ARI) 计划的奖项将帮助加州大学河滨分校化学系升级现有的 500 MHz NMR。 该设备将加强以下多个领域的研究：（1）人类红细胞、肽中的二硫键以及肽与肝素的相互作用（2）维生素D-蛋白质复合物中维生素D的结构研究（3）非标准核酸结构的测定（4）低势垒氢键在酶催化中的作用研究，以及（5） 具有生物学意义的大分子结构的结构-功能关系。 核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具。 它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于进行前沿研究的化学家来说，获得最先进的核磁共振波谱分析至关重要。 这些 NMR 研究的结果可用于聚合物、催化和生物学等领域。