Interaction of the Hippocampal Formation and Prefrontal Cortex in Learning and Memory

海马结构和前额叶皮层在学习和记忆中的相互作用

• 批准号: 9982889
• 负责人: Mark Moss
• 金额: $ 7.53万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9982889&HistoricalAwards=false
• 关键词: Interaction; Hippocampal; Formation; Prefrontal; Cortex

RE: Lay abstract Proposal IBN-9982889This is a study to determine if two different regions of the brain, each of which have been separately implicated in memory function, actually work with each other to subserve certain aspects of memory. Work in humans from imaging studies suggest this possibility, but the only way to assess this with any degree of confidence, and to have the ability to understand the nature of the relationship, is to perform an experiment in an animal model. In this case, the rhesus monkey, which has a brain that is structured in a very similar manner to that of humans, is the species of choice. Monkeys will undergo selective damage to these two parts of the brain, one in the temporal lobe, and the other in the frontal lobe. For each structure, the damage will be made on one side of the brain, leaving the other side intact. We will then "disconnect" the two remaining structures to see if this produces a change in how the animals learn and remember. If a significant change occurs, we will have obtained initial evidence in determining that the two different structures participate together in learning and memory function. This study could have important implications in the assessment of memory function in certain disease states and could have eventual bearing on memory rehabilitation efforts.

RE：简单摘要提案 IBN-9982889 这是一项研究，旨在确定大脑的两个不同区域（每个区域分别与记忆功能有关）是否实际上相互协作以促进记忆的某些方面。 人体成像研究表明了这种可能性，但以任何程度的置信度评估这一点并能够理解这种关系的本质的唯一方法是在动物模型中进行实验。 在这种情况下，恒河猴是首选物种，因为它的大脑结构与人类非常相似。 猴子的大脑的这两个部分会受到选择性损伤，一个位于颞叶，另一个位于额叶。 对于每种结构，大脑的一侧都会受到损害，而另一侧则完好无损。 然后，我们将“断开”剩余的两个结构，看看这是否会改变动物的学习和记忆方式。 如果发生重大变化，我们将获得初步证据来确定这两种不同的结构共同参与学习和记忆功能。 这项研究可能对某些疾病状态下记忆功能的评估具有重要意义，并可能最终对记忆康复工作产生影响。