Enantioselective Synthesis of b-amino acids

b-氨基酸的对映选择性合成

• 批准号: 9983680
• 负责人: Mukund Sibi
• 金额: $ 36万
• 依托单位: North Dakota State University Fargo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-15 至 2003-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9983680&HistoricalAwards=false
• 关键词: Enantioselective; Synthesis; amino; acids

The focus of this research is to develop methodology for the enantioselective addition of nitrogen nucleophiles to enamides and alkylidene malonate using catalytic amounts of chiral Lewis acids. Further, a complementary chiral Lewis acid-mediated protocol in which carbon nucleophiles add selectively to N-substituted methylidene malonates will be developed. The resulting methodology will be used for the preparation indolizidine and pyrrolizidine alkaloids with biological activity.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Mukund Sibi of the Department of Chemistry at North Dakota State University. Professor Sibi will develop new methodology for the preparation of optically active beta-amino acids. The research could have broader impact in the synthesis of compounds and materials of interest to the pharmaceutical and agricultural industries.

本研究的重点是发展催化量的手性刘易斯酸催化含氮亲核试剂对烯酰胺和丙二酸亚烷基酯的不对称加成反应。 此外，一个互补的手性刘易斯酸介导的协议，其中碳亲核试剂选择性地添加到N-取代的亚甲基丙二酸酯将被开发。 由此产生的方法将用于制备具有生物活性的吲哚里西啶和吡咯里西啶生物碱。有了这个奖项，有机和大分子化学计划正在支持北达科他州州立大学化学系的Mukund西比博士的研究。 西比教授将开发制备光学活性β-氨基酸的新方法。 该研究可能会对制药和农业行业感兴趣的化合物和材料的合成产生更广泛的影响。