Enantioselective Synthesis of b-amino acids

b-氨基酸的对映选择性合成

• 批准号: 0316203
• 负责人: Mukund Sibi
• 金额: --
• 依托单位: North Dakota State University Fargo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-15 至 2007-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316203&HistoricalAwards=false
• 关键词: Enantioselective; Synthesis; amino; acids

The focus of this research involves the use of achiral templates to impact face selectivity and enhanced reactivity in the catalytic preparation of beta-amino acids. The project will develop three complementary methods for enantiocontrol using the concept of chiral relay: chiral relay in achiral templates, chiral relay in chiral ligands and chiral relay in achiral additives. In terms of practical value, alpha, beta-disubstituted beta-amino acids will be prepared and exo selective nitrone and nitrile oxide cycloadditions, Reformatsky reactions, allylations and pinacol couplings will be studied. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Mukund Sibi of the Department of Chemistry at North Dakota State University Fargo. Dr. Sibi will focus his work on developing catalytic methodology for the synthesis of complex beta-amino acids in enantiomerically pure form. Beta-amino acids are of significance due to their biological properties and the project will have broader impacts in the pharmaceutical industry. The project also provides an excellent venue for the training of undergraduate, graduate and postgraduate students.

本研究的重点涉及使用非手性模板剂来影响β-氨基酸的催化制备中的面选择性和增强的反应性。 该项目将开发三种互补的方法，用于对映体控制使用手性接力的概念：手性接力在非手性模板，手性接力在手性配体和手性接力在非手性添加剂。 在实用价值方面，将制备α，β-二取代的β-氨基酸，并将研究外选择性硝酮和腈氧化物环加成，Reformatsky反应，烯丙基化和频哪醇偶联。有了这个奖项，有机和高分子化学计划正在支持北达科他州州立大学法戈化学系的Mukund西比博士的研究。 西比博士的工作重点是开发催化方法，用于合成对映体纯形式的复杂β-氨基酸。 β-氨基酸由于其生物学特性而具有重要意义，该项目将在制药行业产生更广泛的影响。 该项目还为本科生、研究生和研究生的培训提供了一个极好的场所。