CAREER: Alkenyl(aryl)iodanes: Investigations of Reactivity and New Syntheses

本研究的重点是烯基（芳基）碘烷作为合成试剂的开发。 高能初级乙烯基阳离子的产生和在亲核取代反应中使用烯基（芳基）碘鎓盐和炔基（芳基）碘鎓盐将被探索。 还将制备新的环状（苯碘多索或苯碘多索酮）烯基碘烷，并将检查试剂的实用范围。 改造本科生实验室和引入基于计算机的分子建模是两个领域，将通过该奖项得到加强。有了这个职业奖，有机和高分子化学计划是支持博士的研究和教育活动。罗伯特J.欣克尔的化学系在威廉玛丽学院。 Hinkle教授将专注于研究高价碘化学的各个方面，目标是开发新的合成试剂。 该项目的教育重点涉及课程开发和本科生研究。

The focus of this research is the development of alkenyl(aryl)iodanes as synthetic reagents. The generation of high-energy primary vinyl cations and the use of alkenyl(aryl)iodonium and alkynyl(aryl)iodonium salts in nucleophilic substitution reactions will be explored. New cyclic (benziodoxole or benziodoxolone) alkenyliodanes will also be prepared and the scope of utility for the reagents will be examined. Revamping of the undergraduate laboratories and introduction of computer-based molecular modeling are two areas that will be enhanced by the award.With this CAREER award,the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Robert J. Hinkle of the Department of Chemistry at the College of William & Mary. Professor Hinkle will focus his research on various aspects of hypervalent iodine chemistry with the goal of developing new synthetic reagents. The educational foci of the project involve course development and undergraduate research.