MRPG: Investigations on the Role of Calcitonin in Reproduction and Development of the Atlantic Stingray

MRPG：降钙素在大西洋黄貂鱼繁殖和发育中作用的研究

• 批准号: 9986070
• 负责人: James Gelsleichter
• 金额: $ 1.8万
• 依托单位: Mote Marine Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9986070&HistoricalAwards=false
• 关键词: MRPG; Investigations; Role; Calcitonin; Reproduction

Calcitonin is a phylogenetically ancient hormone that is produced by the parafollicular C-cells of the thyroid gland in mammals and the ultimobranchial gland of all jawed non-mammalian vertebrates. Despite over 35 years of active research and recent use of calcitonin as a therapeutic drug for osteopathic diseases, little is known about the definitive role of this enigimatic hormone in vertebrate physiology. The present study will characterize the relationships between three processes and calcitonin bioactivity in the Atlantic stingray (Dasyatis sabina), a well-studied elasmobranch species. Along with histologic observations on the activity of the ultimobranchial gland, these indicators of calcitonin bioactivity will be correlated with embryogenic, developmental, and reproductive events in embryonic, neonatal, and reproductively active male and female D. sabina. Preliminary information derived from this Minority Research Planning Study will be used to develop a focused research plan for identifying the definitive role of calcitonin in elasmobranch fishes, the oldest extant vertebrate group to possess this hormonal system.

降钙素是一种遗传学上古老的激素，由哺乳动物甲状腺的滤泡旁C细胞和所有有颌非哺乳类脊椎动物的后鳃腺产生。 尽管有超过35年的积极研究和最近使用的降钙素作为骨病的治疗药物，很少有人知道这种enigimatic激素在脊椎动物生理学的决定性作用。 本研究将描述三个过程和降钙素生物活性之间的关系，在大西洋黄貂鱼（Dasyatis sabina），一个研究良好的板鳃类物种。 沿着对后鳃腺活性的组织学观察，这些降钙素生物活性的指标将与胚胎、新生儿和生殖活跃的雄性和雌性D的胚胎发生、发育和生殖事件相关。萨宾娜。 来自少数研究规划研究的初步信息将用于制定一个重点研究计划，以确定降钙素在板鳃类鱼类中的决定性作用，板鳃类鱼类是现存最古老的脊椎动物群体，拥有这种激素系统。