Structural and functional characterisation of PI3Kgamma, uniquely activated by p101.

由 p101 独特激活的 PI3Kgamma 的结构和功能表征。

• 批准号: DP1095263
• 负责人: Prof Shaun McColl
• 金额: $ 22.99万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1095263
• 关键词: Structural; functional; characterisation; PI3Kgamma; uniquely

The movement of cells is involved in all aspects of life including development, growth and maintenance of organisms. In spite of this, our understanding of the mechanism involved in cell migration is limited. There are a number of conditions in which the ability to control cell movement would be of significant benefit. Examples include autoimmune conditions, asthma and cancer, the social and economic burdens of which account for billions of dollars and millions of Australians. This project aims to understand one of the major mechanisms that controls cell migration, which is expected to produce significant economic and social outcomes in the areas of basic science knowledge, human health, and biotechnology.

细胞的运动涉及生命的各个方面，包括生物体的发育、生长和维持。 尽管如此，我们对细胞迁移机制的理解仍然有限。 在许多情况下，控制细胞运动的能力将带来显着的好处。 例子包括自身免疫性疾病、哮喘和癌症，这些疾病给澳大利亚带来了数十亿澳元和数百万澳大利亚人的社会和经济负担。该项目旨在了解控制细胞迁移的主要机制之一，预计将在基础科学知识、人类健康和生物技术领域产生重大的经济和社会成果。