Undergraduate Research Program in Biochemistry

生物化学本科研究计划

• 批准号: 9988059
• 负责人: Chris Craney
• 金额: $ 15万
• 依托单位: Occidental College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2005-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9988059&HistoricalAwards=false
• 关键词: Undergraduate; Research; Program; Biochemistry

ABSTRACT Craney Proposal # DBI - 9988059This proposal from Occidental's Biochemistry Program will provide a summer research experience for eight undergraduates per year for three years, half of whom will be recruited from community colleges. Many of the community colleges that will be contacted have very large minority student populations, and a special thrust of this proposal is to encourage and enable these minority students to participate in the program and thus enhance their opportunity to pursue a degree in biochemistry. Occidental College's previous thirteen-year experience with community college students working in a summer research program in chemistry suggests these students generally have little or no opportunity to experience the excitement of scientific research at their local institution.Occidental College has long held a position of leadership in undergraduate research. The Biochemistry Program is jointly administered by faculty from both the Biology and Chemistry Departmepts. These departments are highly ranked in a number of undergraduate research categories and this strength will contribute to the proposed project. The experience gained in the previous thirteen-year undergraduate research program involving community college students in the Chemistry Department was recognized by one of the ten nationwide Merck Science Innovation Awards (1989), an NSF Special Creativity Award (1994), contributed to a NSF-AIRE award (1998) and a HHMI award (1996). The well-documented success of the program at Occidental strongly suggests this proposal will have a significant impact on the student participants. Furthermore, as demonstrated in the past, support from the REU program has been crucial in gaining additional support for the community college program from private sources.Students will work on the following on-going projects: (1) Kinetic Studies of Human Erythrocyte Glucose-6-phosphate Dehydrogenase Dimers (G6PD); (2) Molecular genetics of predation by the bacterial predator, Bdellovibrio bacteriovorus; (3) Biophysical Studies on Phospholipid Membranes; (4) Regulation of Immunoglobulin VDJ Rearrangement by a Mouse/Human Chimeric Heavy Chain; (5) Study on PQQ-dependent soluble glucose dehydrogenase (sGDH); and (6) Molecular Evolution of Ryanodine Receptor (RyR) Calcium Channels.

摘要 克雷尼 提案# DBI -9988059来自西方生物化学项目的这一提案将为每年8名本科生提供为期三年的暑期研究经验，其中一半将从社区学院招募。 将联系的许多社区学院都有大量少数族裔学生，该提案的一个特别目的是鼓励并使这些少数族裔学生能够参与该计划，从而增加他们攻读生物化学学位的机会。 西方学院过去13年的经验表明，这些学生通常很少或根本没有机会在当地机构体验科学研究的兴奋。西方学院长期以来一直在本科生研究中处于领先地位。 生物化学课程由生物学和化学系的教师共同管理。 这些部门在一些本科研究类别中排名很高，这种实力将有助于拟议的项目。 在以前的13年本科研究计划中获得的经验，涉及社区学院的学生在化学系被认可的十个全国默克科学创新奖（1989年），NSF特别创造力奖（1994年）之一，促成了NSF-AIRE奖（1998年）和HHMI奖（1996年）。 该计划在西方的成功有力地证明了这一建议将对学生参与者产生重大影响。 此外，正如过去所证明的那样，REU项目的支持对于社区大学项目从私人来源获得额外支持至关重要。学生将参与以下正在进行的项目：（1）人类红细胞葡萄糖-6-磷酸脱氢酶二聚体（G6 PD）的动力学研究;（2）细菌捕食者蛭弧菌捕食的分子遗传学;（3）生物学研究。（3）磷脂膜的生物物理学研究;（4）小鼠/人嵌合重链对免疫球蛋白VDJ重排的调节;（5）PQQ依赖性可溶性葡萄糖脱氢酶（sGDH）的研究;（6）Ryanodine受体（RyR）钙通道的分子进化。