Undergraduate Research Program in Biochemistry

Craney提案# DBI - 9988059来自Occidental生物化学项目的提案将为每年8名本科生提供为期三年的暑期研究经验，其中一半将从社区学院招募。许多将要接触的社区大学都有大量的少数族裔学生，而这项提议的一个特别推动力是鼓励和使这些少数族裔学生参与该计划，从而增加他们攻读生物化学学位的机会。西方学院过去13年与社区大学学生在化学暑期研究项目中工作的经验表明，这些学生通常很少或根本没有机会在当地机构体验科学研究的兴奋。西方学院在本科生研究方面一直处于领先地位。生物化学课程由生物系和化学系的教员共同管理。这些系在一些本科研究类别中排名很高，这一优势将有助于拟议的项目。在过去13年的本科研究项目中，化学系的社区大学生获得的经验获得了全国十大默克科学创新奖之一（1989年）、美国国家科学基金会特别创意奖（1994年）、美国国家科学基金会aire奖（1998年）和HHMI奖（1996年）的认可。西方学院项目的成功充分证明，这一提议将对学生参与者产生重大影响。此外，正如过去所证明的那样，REU计划的支持对于从私人来源获得社区大学计划的额外支持至关重要。学生将从事以下正在进行的项目：(1)人红细胞葡萄糖-6-磷酸脱氢酶二聚体（G6PD）动力学研究；(2)细菌捕食者Bdellovibrio bacteriovorus捕食的分子遗传学；(3)磷脂膜生物物理研究；(4)人/鼠嵌合重链对免疫球蛋白VDJ重排的调控作用；(5) pqq依赖性可溶性葡萄糖脱氢酶（sGDH）的研究；(6) Ryanodine受体（RyR）钙通道的分子进化。

ABSTRACT Craney Proposal # DBI - 9988059This proposal from Occidental's Biochemistry Program will provide a summer research experience for eight undergraduates per year for three years, half of whom will be recruited from community colleges. Many of the community colleges that will be contacted have very large minority student populations, and a special thrust of this proposal is to encourage and enable these minority students to participate in the program and thus enhance their opportunity to pursue a degree in biochemistry. Occidental College's previous thirteen-year experience with community college students working in a summer research program in chemistry suggests these students generally have little or no opportunity to experience the excitement of scientific research at their local institution.Occidental College has long held a position of leadership in undergraduate research. The Biochemistry Program is jointly administered by faculty from both the Biology and Chemistry Departmepts. These departments are highly ranked in a number of undergraduate research categories and this strength will contribute to the proposed project. The experience gained in the previous thirteen-year undergraduate research program involving community college students in the Chemistry Department was recognized by one of the ten nationwide Merck Science Innovation Awards (1989), an NSF Special Creativity Award (1994), contributed to a NSF-AIRE award (1998) and a HHMI award (1996). The well-documented success of the program at Occidental strongly suggests this proposal will have a significant impact on the student participants. Furthermore, as demonstrated in the past, support from the REU program has been crucial in gaining additional support for the community college program from private sources.Students will work on the following on-going projects: (1) Kinetic Studies of Human Erythrocyte Glucose-6-phosphate Dehydrogenase Dimers (G6PD); (2) Molecular genetics of predation by the bacterial predator, Bdellovibrio bacteriovorus; (3) Biophysical Studies on Phospholipid Membranes; (4) Regulation of Immunoglobulin VDJ Rearrangement by a Mouse/Human Chimeric Heavy Chain; (5) Study on PQQ-dependent soluble glucose dehydrogenase (sGDH); and (6) Molecular Evolution of Ryanodine Receptor (RyR) Calcium Channels.