Ultrafast Spectroscopy and Other Applications of Lasers in Chemistry

超快光谱学和激光在化学中的其他应用

• 批准号: 9988138
• 负责人: Robin Hochstrasser
• 金额: $ 53.37万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9988138&HistoricalAwards=false
• 关键词: Ultrafast; Spectroscopy; Other; Applications; Lasers

Professor Robin Hochstrasser of the University of Pennsylvania is funded by the Experimental Physical Chemistry program to perform experiments on liquid phase chemical dynamics. This proposal represents the systematic development of two-dimensional time-resolved infrared spectroscopies, which Professor Hochstrasser has pioneered. These methods, which have analogs in the microwave region using NMR, can yield highly detailed information about molecular vibrational dynamics and coupling and the structures of the liquid samples themselves. Two dimensional IR studies on polypeptides are aimed at improving our understanding of the structure and dynamics of proteins. Other multidimensional laser experiments are aimed at gaining new insights into the structure and dynamics of liquids, including neat water, and polymers. The work on two-dimensional infrared spectroscopy is extremely timely in addressing the need for new methods to provide breakthroughs in determining protein, polymer and liquid structures. Instead of the traditional way of thinking about molecules as discrete particles in solution, this work introduces a new paradigm -- molecules are considered as extended networks of coupled vibrators. Accurate pictures of liquid structures provide some of the key information necessary for addressing biomolecular and environmental problems.

宾夕法尼亚大学的Robin Hochstrasser教授由实验物理化学计划资助，进行液相化学动力学实验。 这一建议代表了Hochstrasser教授开创的二维时间分辨红外光谱的系统发展。 这些方法在微波区域使用NMR具有类似物，可以产生关于分子振动动力学和耦合以及液体样品本身的结构的高度详细的信息。多肽的二维红外研究旨在提高我们对蛋白质结构和动力学的理解。 其他多维激光实验旨在获得对液体（包括纯净水和聚合物）结构和动力学的新见解。 二维红外光谱的工作非常及时地解决了对新方法的需求，为确定蛋白质，聚合物和液体结构提供了突破。 与传统的将分子看作溶液中的离散粒子的方法不同，这项工作引入了一种新的范式--将分子看作是耦合振子的扩展网络。 液体结构的精确图像为解决生物分子和环境问题提供了一些必要的关键信息。