U.S.-France Cooperative Research: The Role of bcl-2 Family Proteins in Protein Translocation Across Mitochondrial Membranes

美法合作研究：bcl-2 家族蛋白在线粒体膜蛋白易位中的作用

• 批准号: 0003797
• 负责人: Kathleen Kinnally
• 金额: $ 0.97万
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0003797&HistoricalAwards=false
• 关键词: U.S.; France; Cooperative; Research; Role

0003797KinnallyThis three-year award for U.S.-France cooperative research in cellular biology involves Kathleen W. Kinnally and her research group at New York University and Stephan Thierry Manon of the Universite de Bordeaux II in Bordeaux, France. The collaboration is aimed at defining the role of bcl-2 proteins in protein translocation across mitochondrial membranes. The bcl-2 family of proteins found in yeast regulate the release of mitochondrial proteins that cause cell death. Experiments are planned to determine the fundamental mechanism by which the bcl-2 family regulates this release and how the proteins are transported across membrane barriers. The US investigator brings to this collaboration expertise in electrophysiology techniques applied to native and reconstituted mitochondria membranes. This is complemented by French expertise in performing protein import experiments and in generating yeast and yeast mitochondrial mutants.This award represents the US side of a joint proposal to the NSF and the French National Center for Scientific Research (CNRS). NSF will cover travel funds and living expenses for the US investigator. The CNRS will support the visits of the French researcher to the United States. The collaboration will advance fundamental understanding into the mechanism by which proteins are translocated across membranes. These processes are important in many cellular functions including signaling, secretion, biogenesis of cell structures, compartmentation, and the mechanisms controlling tissue stability (homeostasis) and organogenesis.

0003797 KinnallyThis三年奖为美国-法国细胞生物学合作研究涉及凯瑟琳W。Kinnally和她在纽约大学的研究小组以及法国波尔多的波尔多第二大学的Stephan Thierry Manon。 该合作旨在确定bcl-2蛋白在线粒体膜蛋白质易位中的作用。在酵母中发现的bcl-2蛋白家族调节导致细胞死亡的线粒体蛋白的释放。 实验计划确定bcl-2家族调节这种释放的基本机制以及蛋白质如何穿过膜屏障。美国研究人员带来了这项合作的专业知识，在电生理技术应用于天然和重建线粒体膜。 此外，法国还在蛋白质进口实验、酵母和酵母线粒体突变体的生产方面拥有专业知识。该奖项代表了美国方面向NSF和法国国家科学研究中心（CNRS）提出的联合建议。 NSF将支付美国研究者的差旅费和生活费。 CNRS将支持法国研究员访问美国。这项合作将推进对蛋白质跨膜转运机制的基本理解。 这些过程在许多细胞功能中是重要的，包括信号传导、分泌、细胞结构的生物发生、区室化以及控制组织稳定性（稳态）和器官发生的机制。