U.S.-Japan Joint Seminar: Learning Nature's Strategies for Making Natural Products: Pathways, Mechanisms, Functional Genomics, and Biosynthetic Applications

0003819 Begley该奖项支持美国科学家参与美国-日本关于学习自然界制造天然产品的战略的讨论会：途径、机制、功能基因组学和生物合成应用，将于2001年6月24日至29日在阿拉斯加格德伍德举行。 共同组织者是康奈尔大学教授Tadhg Begley和日本东京大学教授Yutaka Ebizuka。 在基因组学的影响下，生物合成领域很可能在未来十年内经历重大的增长和发展。 生物合成是一个重要的研究领域，原因有很多：从基本的角度来看，为了了解细胞如何工作，了解不同环境中细胞使用的化学逻辑是至关重要的。 从实际的角度来看，许多天然产物在医学中很重要，几乎所有的前25种药物都是天然产物或基于天然产物。 研讨会的主要目的是讨论对天然产物生物合成感兴趣的科学家如何利用基因组测序产生的大量信息，并最有效地为功能基因组学做出贡献。 来自广泛学科背景的参与者之间的智力互动将对这种增长的发生产生强烈影响。 研讨会将包括以下主题：1）90多种细菌的全基因组测序; 2）开发基因组学研究的新工具，并将其应用于生物合成; 3）操纵生物合成基因簇以产生新的聚酮和多肽抗生素; 4）阐明新的萜烯生物合成途径; 5）萜烯、聚酮化合物、维生素和β-内酰胺生物合成途径中生物合成酶的结构研究; 6）研究不可培养土壤微生物生物合成的新技术。 研讨会的组织者作出了特别努力，让年轻的研究人员既参加研讨会，又作为观察员参加。 与日本专家在这一领域的想法和数据交流将使美国参与者能够推进自己的工作，并为未来的合作项目奠定基础。 将在万维网上传播关于讨论会的资料。

0003819BegleyThis award supports the participation of American scientists in a U.S.-Japan seminar on learning nature's strategies for making natural products: pathways, mechanisms, functional genomics and biosynthetic applications, to be held in Girdwood, Alaska, from June 24-29, 2001. The co-organizers are professors Tadhg Begley of Cornell University and Professor Yutaka Ebizuka of Tokyo University in Japan. Under the impact of genomics, the field of biosynthesis is likely to undergo major growth and development over the next decade. Biosynthesis is an important field of study for many reasons: From a fundamental point of view, it is essential to understand the chemical logic used by cells from diverse environments, in order to understand how the cell works. From a practical point of view, many natural products are important in medicine and almost all of the top 25 drugs are either natural products or are based on them. The primary aim of the seminar is to discuss how scientists interested in biosynthesis of natural products can exploit the enormous amount of information being generated from genome sequencing and most effectively contribute to functional genomics. The intellectual interactions among the participants, drawn from a broad range of disciplinary backgrounds, will have a strong influence on how this growth occurs. The Seminar will consist of the following topics: 1) complete genome sequencing for more than 90 bacteria; 2) development of new tools in genomics research with applications in biosynthesis; 3) manipulation of biosynthetic gene clusters to generate new polyketide and polypeptide antibiotics; 4) elucidation of a new terpene biosynthesis pathway; 5) structural studies on biosynthetic enzymes in the terpene, polyketide, vitamin and b-lactam biosynthetic pathways; and 6) new techniques for studying biosynthesis in unculturable soil microorganisms. Seminar organizers have made a special effort to involve younger researchers as both participants and observers. The exchange of ideas and data with Japanese experts in this field will enable U.S. participants to advance their own work, and will set the stage for future collaborative projects. Dissemination of information on the seminar will be available on the World Wide Web.