A Multi-User Server for Bioinformatics Data Storage, Distribution and Analysis

0070396Russel meinta生物信息学数据存储、分发和分析的多用户服务器根据这份合同，俄勒冈州立大学（OSU）将获得一台多用户计算机服务器，用于支持生物计算联盟（BCC）网络的生物信息学数据存储、分发和分析。该联盟由七个研究单位组成：基因研究与生物技术中心（CGRB），植物学与植物病理学，昆虫学，食品科学与技术，园艺学，微生物学和动物学。联盟网络还支持与研究小组密切相关的学术项目。7名独立实验室成员来自不属于联盟的部门。联盟网络支持800多个个人帐户，该网络目前基于两台服务器：一台是Sun E4000（1998年安装），用于基因、基因组、系统发育和GIS数据分析；另一台是Sun 670MP（使用时间：7年），用于为联盟成员提供电子邮件、网络服务和管理支持。这笔奖金将用于取代已经过时的Sun 670MP。基因研究数据的指数级增长支持了对比目前使用的服务器容量大得多的服务器的需求。第二台服务器将允许实现数据库驱动的存档、检索和数据分析系统。这将支持多个用户同时存储和检索大量数据，并允许使用基于网络的技术将这些信息分发给校园内任何地方的研究人员。新服务器将为Sun E4000提供重要的备份，以确保即使其中一台服务器停止服务，研究也能继续进行。CGRB目前每周产生超过1000兆字节（1g字节）的研究数据。随着基因组学研究的增加和DNA微阵列芯片读取器、毛细管测序系统和数字荧光显微镜系统等新技术的加入，预计在不久的将来产生的数据量将增加三倍。五大用户群体的研究项目如下：分析连续字符的演化模式；昆虫的系统发育、生物地理和修订研究以及基于网络的标本和昆虫收集数据库的建设；番茄生长素与细胞分裂素相互作用的研究及番茄突变体dgt的鉴定外生菌根真菌群体遗传学研究并将杨树作为树木基因工程的模式系统进行研究，重点研究如何控制开花，以建立一个可靠的系统来包含转基因物质。有超过100名与该联盟有关的主要研究人员将从这个新服务器中受益。

0070396Russel MeintsA Multi-User Server for Bioinformatics Data Storage, Distribution and AnalysisWith this award, Oregon State University (OSU) will obtain a multi-user computer server to support bioinformatics data storage, distribution, and analysis for the Biological Computing Consortium (BCC) network. This Consortium is comprised of seven research units: The Center for Gene Research & Biotechnology (CGRB), and the Departments of Botany and Plant Pathology, Entomology, Food Science and Technology, Horticulture, Microbiology and Zoology. The Consortium network also supports academic programs closely associated with the research groups. Seven individual laboratory members come from departments that are not part of the Consortium. Over 800 individual accounts are supported from the Consortium network which is currently based on two servers: a Sun E4000 (installed 1998) for genetic, genomic, phylogenetic, and GIS data analysis and a Sun 670MP (age: 7 years) that is used to provide e-mail, web services, and administrative support for the Consortium members.This award will be used to replace the Sun 670MP, which has reached obsolescence. Theexponential growth of data from genetic research supports the need for the much larger capacity server than the one currently in use. This second server will allow implementation of a database driven archival, retrieval and data analysis system. This will support storage and retrieval of large amounts of data for multiple simultaneous users and allow this information to be distributed using web-based technology to researchers anywhere on campus. The new server will provide important back-up for the Sun E4000 to ensure that the research can continue even if one of the servers is out of service. The CGRB currently generates more than 1000 Megabytes (1 Gbyte) of research data per week. The amount of data that is generated is expected to triple in the near future with the increase in genomics research and the addition of new technologies such as DNA micro-array chip readers, capillary sequencing systems, and digital fluorescence microscopy systems.The research projects of the five major user groups are as follows: analyzing evolutionary patterns in continuous characters; phylogenetic, biogeographic and revisionary studies of insects and construction of web-based specimen and insect collection databases; studies of auxin and cytokinin interactions in tomato and identifying the diageotropica (dgt) mutant of tomato; researching population genetics of ectomycorrhizal fungi; and studying poplars as a model system for tree genetic engineering, which focuses on how to control flowering in order to develop a reliable system to contain transgenic material. There are more than 100 principal investigators associated with the Consortium who will benefit from this new server.