A Multi-User Server for Bioinformatics Data Storage, Distribution and Analysis

用于生物信息学数据存储、分发和分析的多用户服务器

• 批准号: 0070396
• 负责人: Russel Meints
• 金额: $ 8.39万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2002-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0070396&HistoricalAwards=false
• 关键词: Multi; User; Server; Bioinformatics; Data

0070396Russel MeintsA Multi-User Server for Bioinformatics Data Storage, Distribution and AnalysisWith this award, Oregon State University (OSU) will obtain a multi-user computer server to support bioinformatics data storage, distribution, and analysis for the Biological Computing Consortium (BCC) network. This Consortium is comprised of seven research units: The Center for Gene Research & Biotechnology (CGRB), and the Departments of Botany and Plant Pathology, Entomology, Food Science and Technology, Horticulture, Microbiology and Zoology. The Consortium network also supports academic programs closely associated with the research groups. Seven individual laboratory members come from departments that are not part of the Consortium. Over 800 individual accounts are supported from the Consortium network which is currently based on two servers: a Sun E4000 (installed 1998) for genetic, genomic, phylogenetic, and GIS data analysis and a Sun 670MP (age: 7 years) that is used to provide e-mail, web services, and administrative support for the Consortium members.This award will be used to replace the Sun 670MP, which has reached obsolescence. Theexponential growth of data from genetic research supports the need for the much larger capacity server than the one currently in use. This second server will allow implementation of a database driven archival, retrieval and data analysis system. This will support storage and retrieval of large amounts of data for multiple simultaneous users and allow this information to be distributed using web-based technology to researchers anywhere on campus. The new server will provide important back-up for the Sun E4000 to ensure that the research can continue even if one of the servers is out of service. The CGRB currently generates more than 1000 Megabytes (1 Gbyte) of research data per week. The amount of data that is generated is expected to triple in the near future with the increase in genomics research and the addition of new technologies such as DNA micro-array chip readers, capillary sequencing systems, and digital fluorescence microscopy systems.The research projects of the five major user groups are as follows: analyzing evolutionary patterns in continuous characters; phylogenetic, biogeographic and revisionary studies of insects and construction of web-based specimen and insect collection databases; studies of auxin and cytokinin interactions in tomato and identifying the diageotropica (dgt) mutant of tomato; researching population genetics of ectomycorrhizal fungi; and studying poplars as a model system for tree genetic engineering, which focuses on how to control flowering in order to develop a reliable system to contain transgenic material. There are more than 100 principal investigators associated with the Consortium who will benefit from this new server.

0070396Russel Meints 用于生物信息学数据存储、分发和分析的多用户服务器获得此奖项后，俄勒冈州立大学 (OSU) 将获得一台多用户计算机服务器，以支持生物计算联盟 (BCC) 网络的生物信息学数据存储、分发和分析。该联盟由七个研究单位组成：基因研究与生物技术中心（CGRB）以及植物学和植物病理学、昆虫学、食品科学与技术、园艺、微生物学和动物学系。联盟网络还支持与研究小组密切相关的学术项目。 七个单独的实验室成员来自不属于该联盟的部门。联盟网络支持超过 800 个个人帐户，该网络目前基于两台服务器：用于遗传、基因组、系统发育和 GIS 数据分析的 Sun E4000（1998 年安装）和用于为联盟成员提供电子邮件、Web 服务和管理支持的 Sun 670MP（寿命：7 年）。该奖项将用于替换已过时的 Sun 670MP。基因研究数据的指数级增长支持了对比当前使用的服务器容量大得多的服务器的需求。第二台服务器将允许实施数据库驱动的归档、检索和数据分析系统。这将支持多个同时用户的大量数据的存储和检索，并允许使用基于网络的技术将这些信息分发给校园内任何地方的研究人员。新服务器将为Sun E4000提供重要的备份，以确保即使其中一台服务器停止服务，研究也能继续进行。 CGRB 目前每周生成超过 1000 兆字节 (1 GB) 的研究数据。随着基因组学研究的增加以及 DNA 微阵列芯片读取器、毛细管测序系统和数字荧光显微镜系统等新技术的加入，生成的数据量预计在不久的将来将增加两倍。 五个主要用户组的研究项目如下：分析连续性状的进化模式；昆虫的系统发育、生物地理学和修订研究以及基于网络的标本和昆虫收集数据库的建设；研究番茄中生长素和细胞分裂素相互作用并鉴定番茄的 diageotropica (dgt) 突变体；研究外生菌根真菌的群体遗传学；研究杨树作为树木基因工程的模型系统，其重点是如何控制开花，以开发包含转基因材料的可靠系统。与该联盟相关的 100 多名主要调查员将受益于这个新服务器。