Asymmetric Synthesis with Boronic Esters

本研究的重点是利用硼酸化学开发不对称合成方法，并以氯代硼酸酯环合为烯醇酸酯的立体控制合成为例进行探讨。还将研究硼硅酸盐玻璃表面催化的配体交换，将稳定的硼酸酯转化为烷基硼氯胺络合物和二醇亚硫酸盐，以影响有价值的手性董事的回收。此外，该反应还有可能将高度受阻的不对称硼酸酯转化为更具活性的硼烷衍生物。有了这一续期奖项，有机和高分子化学计划将支持华盛顿州立大学化学系的Donald S.Matteson博士的研究。Matteson教授将专注于开发使用硼酸酯化学的不对称合成方法。该研究领域非常适合培养研究生，研究结果可能会对制药和农业产生影响。

he focus of this research is the development of asymmetric methods for synthesis using boronic acid chemistry and, as an example, the stereocontrolled synthesis of small rings via cyclization of chloro boronic esters to enolates will be probed. The borosilicate glass surface catalyzed ligand exchange that converts stable boronic esters to alkylboron chloride amine complexes plus diol sulfites will also be studied in order to affect the recovery of valuable chiral directors. Further, this reaction also has potential for converting highly hindered asymmetric boronic esters into more reactive borane derivatives.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Donald S. Matteson of the Department of Chemistry at Washington State University. Professor Matteson will focus his work on developing asymmetric synthesis methodology using boronic ester chemistry. The area of research is excellent for the training of graduate students and the results of the research could have implications for the pharmaceutical and agricultural industries.